HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >

Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival

This item is licensed under: Creative Commons Attribution 4.0 International

Files in This Item:
fetchObject.pdf4.77 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/57942

Title: Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival
Authors: Kudo, Hiroya Browse this author
Wada, Haruka Browse this author →KAKEN DB
Sasaki, Hajime Browse this author
Tsuji, Hyuma Browse this author
Otsuka, Ryo Browse this author
Baghdadi, Muhammad Browse this author
Kojo, Satoshi Browse this author →KAKEN DB
Chikaraishi, Tatsuya Browse this author →KAKEN DB
Seino, Ken-ichiro Browse this author
Issue Date: 30-Oct-2014
Publisher: Public Library of Science
Journal Title: PLOS one
Volume: 9
Issue: 10
Start Page: e111826
Publisher DOI: 10.1371/journal.pone.0111826
Abstract: Recent progress in regenerative medicine has enabled the utilization of pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) as a donor resource for transplantation. However, immune suppression is still needed when the donor-recipient combination is allogeneic. Protection of ESCs-derived grafts from host immune response might be achieved thought the utilization of immunosuppressive cells generated from ESCs. In the present study, we show that a certain fraction of immunosuppressive cells can be generated from ESCs and help to suppress immune response against allogeneic grafts. ESCs-derived suppressor cells (ES-SCs) resembled macrophages in terms of cell surface molecule and gene expressions. Furthermore, gene expression analysis including microarray showed that ES-SCs have M1/M2 hybrid phenotype with high expression of genes correlated to immunosuppression of T cell response. Indeed, ES-SCs were effective to block allogeneic T cell proliferation in a nitric oxide-dependent manner, and prolonged the survival of ESCs-derived embryoid bodies or cardiomyocytes grafts transplanted into mouse kidney capsule. Thus, we consider the potential use of these ESCs-derived macrophage-like immunosuppressive cells as cellular therapies to promote long-term graft survival in future therapies.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/57942
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清野 研一郎

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University