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Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival

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タイトル: Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival
著者: Kudo, Hiroya 著作を一覧する
Wada, Haruka 著作を一覧する
Sasaki, Hajime 著作を一覧する
Tsuji, Hyuma 著作を一覧する
Otsuka, Ryo 著作を一覧する
Baghdadi, Muhammad 著作を一覧する
Kojo, Satoshi 著作を一覧する
Chikaraishi, Tatsuya 著作を一覧する
Seino, Ken-ichiro 著作を一覧する
発行日: 2014年10月30日
出版者: Public Library of Science
誌名: PLOS one
巻: 9
号: 10
開始ページ: e111826
出版社 DOI: 10.1371/journal.pone.0111826
抄録: Recent progress in regenerative medicine has enabled the utilization of pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) as a donor resource for transplantation. However, immune suppression is still needed when the donor-recipient combination is allogeneic. Protection of ESCs-derived grafts from host immune response might be achieved thought the utilization of immunosuppressive cells generated from ESCs. In the present study, we show that a certain fraction of immunosuppressive cells can be generated from ESCs and help to suppress immune response against allogeneic grafts. ESCs-derived suppressor cells (ES-SCs) resembled macrophages in terms of cell surface molecule and gene expressions. Furthermore, gene expression analysis including microarray showed that ES-SCs have M1/M2 hybrid phenotype with high expression of genes correlated to immunosuppression of T cell response. Indeed, ES-SCs were effective to block allogeneic T cell proliferation in a nitric oxide-dependent manner, and prolonged the survival of ESCs-derived embryoid bodies or cardiomyocytes grafts transplanted into mouse kidney capsule. Thus, we consider the potential use of these ESCs-derived macrophage-like immunosuppressive cells as cellular therapies to promote long-term graft survival in future therapies.
資料タイプ: article
URI: http://hdl.handle.net/2115/57942
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 清野 研一郎

 

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