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A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury
Title: | A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury |
Authors: | Kurokawa, Sei Browse this author | Katsuki, Shinichi Browse this author | Fujita, Tomoki Browse this author | Saitoh, Yusuke Browse this author | Ohta, Hidetoshi Browse this author | Nishikawa, Kouji Browse this author | Sato, Yasushi Browse this author | Sato, Yasuhiro Browse this author | Ohira, Koji Browse this author | Yamada, Masataka Browse this author | Kato, Mototsugu Browse this author →KAKEN DB |
Keywords: | NSAID | Aspirin | Small intestinal injury | Capsule endoscopy | Nutritional parameter |
Issue Date: | Feb-2014 |
Publisher: | Springer japan kk |
Journal Title: | Journal of gastroenterology |
Volume: | 49 |
Issue: | 2 |
Start Page: | 239 |
End Page: | 244 |
Publisher DOI: | 10.1007/s00535-013-0805-2 |
PMID: | 23595613 |
Abstract: | It is not clear what kind of drug is appropriate to heal NSAID-induced enteropathy. Several reports showed the preventive effect of prostaglandin analogue or inducer using healthy subjects who took NSAIDs. However there was no report for healing effect and for patients. The aim of this study was to evaluate the healing effect of rebamipide in patients with NSAIDs-induced enteropathy. In addition, we evaluated for nutritional parameter. This study was conducted as a randomized, double-blinded, placebo-controlled, multicenter trial. Study protocol was approved by each hospital's ethical committees. Patients with LDA and/or NSAID more than 3 months were enrolled. Patients with enteropathy were divided into the placebo and the rebamipide groups. Rebamipide 100 mg three times daily was administered during 4 weeks. Capsule endoscopies were performed at 0 and 4 week. The number of small intestinal ulcer and erosion were evaluated. Total protein was analyzed as nutritional parameter. Sixty one participants were completed this study. Change in number of small intestinal erosion in the rebamipide group was -2.5 +/- A 3.4, and 2.1 +/- A 3.9 in the placebo group (P < 0.0001). Change in number of small intestinal ulcer in the rebamipide group was -0.5 +/- A 1.6, and 0.1 +/- A 0.7 in the placebo group (P = 0.024). Change in serum total protein levels in the rebamipide group was 0.06 +/- A 0.36, and -0.27 +/- A 0.34 in the placebo group (P = 0.0005). Rebamipide has not only the healing effect for NSAIDs-induced enteropathy compared with placebo, but the improvement of nutritional condition. These results showed a tentative therapeutical strategy for chronic NSAIDs users. |
Rights: | The final publication is available at link.springer.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/58005 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 元嗣
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