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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Japanese Journal of Veterinary Research >
Volume 63 Number 1 >
Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice
| Title: | Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice |
| Authors: | Yamashita, Yuma Browse this author | | Nakamura, Teppei Browse this author | | Otsuka-Kanazawa, Saori Browse this author →KAKEN DB | | Ichii, Osamu Browse this author →KAKEN DB | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | folliculogenesis | | MRL/MpJ | | nest breakdown | | oocyte |
| Issue Date: | Feb-2015 |
| Publisher: | Graduate School of Veterinary Medicine, Hokkaido University |
| Journal Title: | Japanese Journal of Veterinary Research |
| Volume: | 63 |
| Issue: | 1 |
| Start Page: | 25 |
| End Page: | 36 |
| Abstract: | In perinatal mice, the ovary undergoes drastic morphological changes, as clusters of oocytes called nests break into smaller cysts and subsequently form individual follicles. We studied perinatal oocyte development in MRL/MpJ mice, and compared it to that observed in C57BL/6 mice between embryonic day 18.5 and postnatal day 4. Throughout the observation period, compared to C57BL/6 mice, MRL/MpJ mice displayed significantly fewer oocytes in their ovaries. Morphologically, there were no clear differences between the strains at embryonic day 18.5. However, the beginning of folliculogenesis, as evidenced by the expression of NOBOX oogenesis homeobox (Nobox) transcript and protein, was more enhanced in MRL/MpJ mice than in C57BL/6 mice at embryonic day 18.5 and postnatal day 0. In addition, developed follicles were more frequently observed in MRL/MpJ mice than in C57BL/6 mice between postnatal days 0 and 4. In conclusion, the oocyte development during nest breakdown and folliculogenesis was accelerated in MRL/MpJ mice when compared to that observed in C57BL/6 mice. |
| Type: | bulletin (article) |
| URI: | http://hdl.handle.net/2115/58140 |
| Appears in Collections: | Japanese Journal of Veterinary Research > Volume 63 Number 1
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Submitter: 獣医学部図書室
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