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Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.63.1.25

Title: Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice
Authors: Yamashita, Yuma Browse this author
Nakamura, Teppei Browse this author
Otsuka-Kanazawa, Saori Browse this author →KAKEN DB
Ichii, Osamu Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: folliculogenesis
MRL/MpJ
nest breakdown
oocyte
Issue Date: Feb-2015
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 63
Issue: 1
Start Page: 25
End Page: 36
Abstract: In perinatal mice, the ovary undergoes drastic morphological changes, as clusters of oocytes called nests break into smaller cysts and subsequently form individual follicles. We studied perinatal oocyte development in MRL/MpJ mice, and compared it to that observed in C57BL/6 mice between embryonic day 18.5 and postnatal day 4. Throughout the observation period, compared to C57BL/6 mice, MRL/MpJ mice displayed significantly fewer oocytes in their ovaries. Morphologically, there were no clear differences between the strains at embryonic day 18.5. However, the beginning of folliculogenesis, as evidenced by the expression of NOBOX oogenesis homeobox (Nobox) transcript and protein, was more enhanced in MRL/MpJ mice than in C57BL/6 mice at embryonic day 18.5 and postnatal day 0. In addition, developed follicles were more frequently observed in MRL/MpJ mice than in C57BL/6 mice between postnatal days 0 and 4. In conclusion, the oocyte development during nest breakdown and folliculogenesis was accelerated in MRL/MpJ mice when compared to that observed in C57BL/6 mice.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/58140
Appears in Collections:Japanese Journal of Veterinary Research > Volume 63 Number 1

Submitter: 獣医学部図書室

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