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Postnatal development of the rat corticospinal tract, with special reference to confocal laser scanning microscopy of growing axons
| Title: | Postnatal development of the rat corticospinal tract, with special reference to confocal laser scanning microscopy of growing axons |
| Other Titles: | ラット皮膚脊髄路の生後発達 : 共焦点レーザー走査顕微鏡による成長軸索の形態学的検討 |
| Authors: | 永島, 雅文1 Browse this author |
| Authors(alt): | Nagashima, Masabumi1 |
| Keywords: | corticospinal tract | | Growth cone | | Collateral branch | | Pioneer axon | | Follower axon | | DiI | | Confocal laser scanning microscopy | | Rat |
| Issue Date: | 30-Jun-1994 |
| Publisher: | Hokkaido University |
| Publisher DOI: | 10.1016/0168-0102(94)90011-6 |
| Abstract: | The corticospinal tract within the spinal cord of the neonatai rats, ranging from postnatal day 1 （P1） to P11， was investigated by using anterograde labeling with DiI optimized by confocal laser scanning microscopy． This method enabled us to observe a thick section containing a large population of the labeled axons and to acquire fine structure images with sufficient resolution． As advantages，novel views of diversity emerged in the developing axons and their collaterals． First， the individual parent axons showed unrestrained trajectories within the main bundle which constantly occupied the ventral part of the dorsal column．Second， there was an aberrant bundle which ran ventrally apart frorn the rnain bundle and converged into it． Third，several projection collaterals branched from the parent axons and left the main bundle in various directions, whereas the majority of them branched off at approximately a right angle． In addition， the main bundle consisted of a small number of pioneer axons and numerous follower ones.The pioneer axon tips were first found in the cervical level on P1， in the thoracic level on P2， in the lumbar level on P5 and in the sacral level on P7． The follower axon tips were observed in a wide range from away from the pioneer tips to just behind them. Projection collaterals were arborized within the gray matter and their arbors entered the dorsal horn， the intermediate substance or the ventral horn in the transverse plane. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 乙第4555号 |
| Degree Level: | 博士 |
| Degree Discipline: | 医学 |
| Rights: | DOI:10.1016/0168-0102(94)90011-6 Neuroscience Research 19(1) p81-92 1994 |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/58185 |
| Appears in Collections: | 学位論文 (Theses) > 博士 （医学）
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