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Combination of root surface modification with BMP-2 and collagen hydrogel scaffold implantation for periodontal healing in beagle dogs

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Title: Combination of root surface modification with BMP-2 and collagen hydrogel scaffold implantation for periodontal healing in beagle dogs
Authors: Kato, Akihito Browse this author →KAKEN DB
Miyaji, Hirofumi Browse this author →KAKEN DB
Ishizuka, Ryosuke Browse this author
Tokunaga, Keisuke Browse this author
Inoue, Kana Browse this author
Kosen, Yuta Browse this author
Yokoyama, Hiroyuki Browse this author
Sugaya, Tsutomu Browse this author →KAKEN DB
Tanaka, Saori Browse this author →KAKEN DB
Sakagami, Ryuji Browse this author →KAKEN DB
Kawanami, Masamitsu Browse this author →KAKEN DB
Keywords: Ankylosis
bone morphogenetic protein-2
collagen hydrogel
one-wall infrabony defects
periodontal attachment
periodontal wound healing
regenerative scaffold
Issue Date: 30-Jan-2015
Publisher: Bentham Open
Journal Title: The Open Dentistry Journal
Volume: 9
Start Page: 52
End Page: 59
Publisher DOI: 10.2174/1874210601509010052
PMID: 25674172
Abstract: Objective: Biomodification of the root surface plays a major role in periodontal wound healing. Root surface modification with bone morphogenetic protein (BMP) stimulates bone and cementum-like tissue formation; however, severe ankylosis is simultaneously observed. Bio-safe collagen hydrogel scaffolds may therefore be useful for supplying periodontal ligament cells and preventing ankylosis. We examined the effects of BMP modification in conjunction with collagen hydrogel scaffold implantation on periodontal wound healing in dogs. Material and Methods: The collagen hydrogel scaffold was composed of type I collagen sponge and collagen hydrogel. One-wall infrabony defects (5 mm in depth, 3 mm in width) were surgically created in six beagle dogs. In the BMP/Col group, BMP-2 was applied to the root surface (loading dose; 1μg/μl), and the defects were filled with collagen hydrogel scaffold. In the BMP or Col group, BMP-2 coating or scaffold implantation was performed. Histometric parameters were evaluated at 4 weeks after surgery. Results: Single use of BMP stimulated formation of alveolar bone and ankylosis. In contrast, the BMP/Col group frequently enhanced reconstruction of periodontal attachment including cementum-like tissue, periodontal ligament and alveolar bone. The amount of new periodontal ligament in the BMP/Col group was significantly greater when compared to all other groups. In addition, ankylosis was rarely observed in the BMP/Col group. Conclusion: The combination method using root surface modification with BMP and collagen hydrogel scaffold implantation facilitated the reestablishment of periodontal attachment. BMP-related ankylosis was suppressed by implantation of collagen hydrogel.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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