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Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear

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Title: Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear
Authors: An, Yan Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
Kitaichi, Yuji Browse this author →KAKEN DB
Nakagawa, Shin Browse this author →KAKEN DB
Wang, Ce Browse this author
Chen, Chong Browse this author
Song, Ning Browse this author
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Mirtazapine
Lithium
Anxiety
Freezing
Contextual fear conditioning
Issue Date: 15-Jan-2015
Publisher: Elsevier
Journal Title: European journal of pharmacology
Volume: 747
Start Page: 13
End Page: 17
Publisher DOI: 10.1016/j.ejphar.2014.11.009
PMID: 25438255
Abstract: Lithium not only has a mood-stabilizing effect but also the augmentation effect of an antidepressant, the mechanism of which remains unclear. Although lithium may augment the effect of mirtazapine, this augmentation has not been confirmed. Using a contextual fear conditioning test in rats, an animal model of anxiety or fear, we examined the effect of subchronic lithium carbonate (in diet) in combination with systemic mirtazapine on the expression of contextual conditioned fear. Mirtazapine (10 mg/kg) reduced freezing one day after fear conditioning dose-dependently, whereas the anxiolytic-like effect of mirtazapine (10 mg/kg) diminished seven days after fear conditioning. When the interval between fear conditioning and testing was seven days, only the combination of subchronic 0.2% Li2CO3 but not 0.05% Li2CO3 with acute mirtazapine (10 mg/kg) reduced freezing significantly. These results indicate that subchronic 0.2% Li2CO3 treatment enhanced the anxiolytic-like effect of systemic mirtazapine. This augmentation therapy might be useful for the treatment of anxiety disorders. (C) 2014 Elsevier B.V. All rights reserved,
Type: article (author version)
URI: http://hdl.handle.net/2115/58243
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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