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Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear

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タイトル: Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear
著者: An, Yan 著作を一覧する
Inoue, Takeshi 著作を一覧する
Kitaichi, Yuji 著作を一覧する
Nakagawa, Shin 著作を一覧する
Wang, Ce 著作を一覧する
Chen, Chong 著作を一覧する
Song, Ning 著作を一覧する
Kusumi, Ichiro 著作を一覧する
キーワード: Mirtazapine
Lithium
Anxiety
Freezing
Contextual fear conditioning
発行日: 2015年 1月15日
出版者: Elsevier
誌名: European journal of pharmacology
巻: 747
開始ページ: 13
終了ページ: 17
出版社 DOI: 10.1016/j.ejphar.2014.11.009
抄録: Lithium not only has a mood-stabilizing effect but also the augmentation effect of an antidepressant, the mechanism of which remains unclear. Although lithium may augment the effect of mirtazapine, this augmentation has not been confirmed. Using a contextual fear conditioning test in rats, an animal model of anxiety or fear, we examined the effect of subchronic lithium carbonate (in diet) in combination with systemic mirtazapine on the expression of contextual conditioned fear. Mirtazapine (10 mg/kg) reduced freezing one day after fear conditioning dose-dependently, whereas the anxiolytic-like effect of mirtazapine (10 mg/kg) diminished seven days after fear conditioning. When the interval between fear conditioning and testing was seven days, only the combination of subchronic 0.2% Li2CO3 but not 0.05% Li2CO3 with acute mirtazapine (10 mg/kg) reduced freezing significantly. These results indicate that subchronic 0.2% Li2CO3 treatment enhanced the anxiolytic-like effect of systemic mirtazapine. This augmentation therapy might be useful for the treatment of anxiety disorders. (C) 2014 Elsevier B.V. All rights reserved,
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/58243
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 井上 猛

 

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