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Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss

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Title: Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
Authors: Oshima, Shigeki Browse this author
Onodera, Shin2 Browse this author →KAKEN DB
Amizuka, Norio Browse this author
Li, Minqi Browse this author
Irie, Kazuharu Browse this author
Watanabe, Satoshi Browse this author
Koyama, Yoshikazu Browse this author
Nishihira, Jun Browse this author
Yasuda, Kazunori Browse this author →KAKEN DB
Minami, Akio Browse this author →KAKEN DB
Authors(alt): 小野寺, 伸2
Keywords: Macrophage migration inhibitory factor
Deficient mice
Issue Date: 20-Feb-2006
Publisher: Elsevier B.V.
Journal Title: FEBS Letters
Volume: 580
Issue: 5
Start Page: 1251
End Page: 1256
Publisher DOI: 10.1016/j.febslet.2006.01.038
PMID: 16442103
Abstract: A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野寺 伸

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