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Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
| Title: | Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss |
| Authors: | Oshima, Shigeki Browse this author | | Onodera, Shin2 Browse this author →KAKEN DB | | Amizuka, Norio Browse this author | | Li, Minqi Browse this author | | Irie, Kazuharu Browse this author | | Watanabe, Satoshi Browse this author | | Koyama, Yoshikazu Browse this author | | Nishihira, Jun Browse this author | | Yasuda, Kazunori Browse this author →KAKEN DB | | Minami, Akio Browse this author →KAKEN DB |
| Authors(alt): | 小野寺, 伸2 |
| Keywords: | Macrophage migration inhibitory factor | | Deficient mice | | Osteoporosis | | Ovariectomy | | Cytokine |
| Issue Date: | 20-Feb-2006 |
| Publisher: | Elsevier B.V. |
| Journal Title: | FEBS Letters |
| Volume: | 580 |
| Issue: | 5 |
| Start Page: | 1251 |
| End Page: | 1256 |
| Publisher DOI: | 10.1016/j.febslet.2006.01.038 |
| PMID: | 16442103 |
| Abstract: | A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease. |
| Relation: | http://www.sciencedirect.com/science/journal/00145793 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/5848 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小野寺 伸
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