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Surgery for recurrent biliary carcinoma : results for 27 recurrent cases

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Title: Surgery for recurrent biliary carcinoma : results for 27 recurrent cases
Authors: Noji, Takehiro Browse this author
Tsuchikawa, Takahiro Browse this author
Mizota, Tomoko Browse this author
Okamura, Keisuke Browse this author
Nakamura, Toru Browse this author
Tamoto, Eiji Browse this author
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: Recurrent biliary malignancy
Extrahepatic cholangiocarcinoma
Gallbladder carcinoma
Surgery
Chemotherapy
Survival
Issue Date: 27-Feb-2015
Publisher: Biomed Central Ltd
Journal Title: World Journal Of Surgical Oncology
Volume: 13
Start Page: 82
Publisher DOI: 10.1186/s12957-015-0507-8
Abstract: Background: Various chemotherapies have been used as best practice to treat recurrent biliary malignancies. Conversely, relatively few surgeries have been described for recurrent extrahepatic biliary carcinoma (RExBC), so whether surgery for RExBC is feasible has remained unclear. This retrospective study was conducted to evaluate the feasibility of surgery for RExBC. Methods: From February 2000 to January 2014, a total of 27 patients, comprising 18 patients with extrahepatic cholangiocarcinoma and 9 patients with gallbladder carcinoma, met our criteria for radical resection of RExBC (resection group). Sites of recurrence consisted of liver metastases (ten patients), local/percutaneous transhepatic cholangio drainage (PTCD) fistula recurrence (eight patients), bile duct recurrence (six patients), and lymph node recurrence (one patient). To evaluate the survival impact of resection, we compared 123 RExBC patients (resection group) with patients who received palliative care (palliative group). Results: Morbidity and mortality rates in the resection group were 6.6% and 0%, respectively. Overall cumulative 5-year survival rates were 23.5% in the resection group and 0% in the palliative group. Median survival time was 21.6 months in the resection group and 9.5 months in the palliative group, showing a significant difference (p < 0.01). No significant differences in cumulative survival were seen between extrahepatic cholangiocarcinoma and gallbladder carcinoma in the resection group. In addition, no significant differences were seen between liver metastases, bile duct recurrence, and local/percutaneous transhepatic biliary drainage (PTBD) fistula recurrence in the resection group. Conclusions: Surgery appears feasible for RExBC and offers longer survival for selected patients.
Rights: http://creativecommons.org/licenses/by/4.0
Type: article
URI: http://hdl.handle.net/2115/58561
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 野路 武寛

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