HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children

Creative Commons LicenseCreative Commons Attribution 4.0 International

Files in This Item:
fetchObject.pdf203.2 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children
Authors: Mitsui, Takahiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Imai, Ayako Browse this author
Sato, Sakiko Browse this author
Miyashita, Chihiro Browse this author
Ito, Sachiko Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Kitta, Takeya Browse this author →KAKEN DB
Moriya, Kimihiko Browse this author →KAKEN DB
Cho, Kazutoshi Browse this author →KAKEN DB
Morioka, Keita Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Nonomura, Katsuya Browse this author →KAKEN DB
Issue Date: 6-Mar-2015
Publisher: Public Library Science
Journal Title: Plos one
Volume: 10
Issue: 3
Start Page: e0120636
Publisher DOI: 10.1371/journal.pone.0120636
Abstract: Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged children. Of the 514 children who participated in a prospective cohort study on birth in Sapporo between 2002 and 2005, the following sex hormone levels were measured in 294 stored cord blood samples (135 boys and 159 girls); testosterone (T), estradiol (E), progesterone, LH, FSH, inhibin B, and insulin-like factor 3 (INSL3). A total of 350 children, who were of school age and could be contacted for this survey, were then requested via mail to send black-and-white photocopies of the palms of both the left and right hands. 2D/4D was calculated in 190 children (88 boys and 102 girls) using photocopies and derived from participants with the characteristics of older mothers, a higher annual household income, higher educational level, and fewer smokers among family members. 2D/4D was significantly lower in males than in females (p<0.01). In the 294 stored cord blood samples, T, T/E, LH, FSH, Inhibin B, and INSL3 levels were significantly higher in samples collected from males than those from females. A multivariate regression model revealed that 2D/4D negatively correlated with INSL3 in males and was significantly higher in males with <0.32 ng/mL of INSL3 (p<0.01). No correlations were observed between other hormones and 2D/4D. In conclusion, 2D/4D in school-aged children, which was significantly lower in males than in females, was affected by prenatal Leydig cell function.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三井 貴彦

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


Feedback - Hokkaido University