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Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats

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Title: Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats
Authors: Ito Kato, Ryoko Browse this author
Tachibana, Kaori Browse this author →KAKEN DB
Hashimoto, Toshikazu Browse this author →KAKEN DB
Takita, Koichi Browse this author
Morimoto, Yuji Browse this author →KAKEN DB
Keywords: Dexmedetomidine
Synaptic plasticity
Long-term potentiation
Issue Date: Dec-2014
Publisher: Springer
Journal Title: Journal of anesthesia
Volume: 28
Issue: 6
Start Page: 828
End Page: 832
Publisher DOI: 10.1007/s00540-014-1853-3
PMID: 24854521
Abstract: The aim of this study was to evaluate the effect of dexmedetomidine (DEX) on hippocampal synaptic activity in vivo. The adult rats used for this study received a intraperitoneal bolus injection of 3, 10, 30, or 100 mu g/kg of DEX or an equivalent volume of saline. Electrophysiological recording of the hippocampal CA1 region was initiated 20 min after drug administration. The results are expressed as the percentages of the population spike amplitude measured just before high-frequency stimulation (HFS). The electrophysiological data were analyzed with an area under the curve (AUC) of 10-60 min after HFS. Moreover, to investigate the sedative dose of DEX in rats, we recorded the duration of loss of spontaneous movement after the administration of each dose of DEX. Intraperitoneal administration of DEX at doses of 30 and 100 mu g/kg induced a range of sedative effects. The AUC measurements were significantly lower in the 30 and 100 mu g/kg groups than in those injected with vehicle (vehicle: 8.81 +/- A 0.49, n = 7; DEX 30 A mu g/kg: 6.02 +/- A 0.99, n = 6; DEX 100 A mu g/kg: 5.10 +/- A 0.43, n = 5; P < 0.05). The results of our in vivo study reveal that sedative doses of DEX impaired the induction of hippocampal long-term potentiation (LTP). These findings may signify a causal link between DEX-induced sedative action and hippocampal LTP suppression, providing a better understanding of the mechanisms underlying the DEX-induced sedative and/or amnestic effect.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 亮子

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