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Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats

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タイトル: Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats
著者: Ito Kato, Ryoko 著作を一覧する
Tachibana, Kaori 著作を一覧する
Hashimoto, Toshikazu 著作を一覧する
Takita, Koichi 著作を一覧する
Morimoto, Yuji 著作を一覧する
キーワード: Dexmedetomidine
Synaptic plasticity
Long-term potentiation
発行日: 2014年12月
出版者: Springer
誌名: Journal of anesthesia
巻: 28
号: 6
開始ページ: 828
終了ページ: 832
出版社 DOI: 10.1007/s00540-014-1853-3
抄録: The aim of this study was to evaluate the effect of dexmedetomidine (DEX) on hippocampal synaptic activity in vivo. The adult rats used for this study received a intraperitoneal bolus injection of 3, 10, 30, or 100 mu g/kg of DEX or an equivalent volume of saline. Electrophysiological recording of the hippocampal CA1 region was initiated 20 min after drug administration. The results are expressed as the percentages of the population spike amplitude measured just before high-frequency stimulation (HFS). The electrophysiological data were analyzed with an area under the curve (AUC) of 10-60 min after HFS. Moreover, to investigate the sedative dose of DEX in rats, we recorded the duration of loss of spontaneous movement after the administration of each dose of DEX. Intraperitoneal administration of DEX at doses of 30 and 100 mu g/kg induced a range of sedative effects. The AUC measurements were significantly lower in the 30 and 100 mu g/kg groups than in those injected with vehicle (vehicle: 8.81 +/- A 0.49, n = 7; DEX 30 A mu g/kg: 6.02 +/- A 0.99, n = 6; DEX 100 A mu g/kg: 5.10 +/- A 0.43, n = 5; P < 0.05). The results of our in vivo study reveal that sedative doses of DEX impaired the induction of hippocampal long-term potentiation (LTP). These findings may signify a causal link between DEX-induced sedative action and hippocampal LTP suppression, providing a better understanding of the mechanisms underlying the DEX-induced sedative and/or amnestic effect.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加藤 亮子


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