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Association of Peripheral Total and Differential Leukocyte Counts with Obesity-Related Complications in Young Adults

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Title: Association of Peripheral Total and Differential Leukocyte Counts with Obesity-Related Complications in Young Adults
Authors: Yoshimura, Aya Browse this author
Ohnishi, Shunsuke Browse this author →KAKEN DB
Orito, Chieko Browse this author
Kawahara, Yukako Browse this author
Takasaki, Hiroyo Browse this author
Takeda, Hiroshi Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Keywords: Inflammation
Insulin resistance
Body fat
Issue Date: Feb-2015
Publisher: Karger
Journal Title: Obesity facts
Volume: 8
Issue: 1
Start Page: 1
End Page: 16
Publisher DOI: 10.1159/000373881
Abstract: Objective: Obesity has been demonstrated to be associated with elevated leukocytes in adults and children. This study assessed the associations between peripheral total and differential leukocyte counts and obesity-related complications in young adults. Methods: 12 obese (median age 21.5 (range 19-28) years, median BMI 35.7 (range 32.0-44.9) kg/m 2) and 11 normal (median age 23 (range 18-27) years, median BMI 19.5 (range 18.1-21.7) kg/m 2) adults were enrolled. Complete blood count and serum levels of liver enzymes, fasting blood glucose, insulin and lipids were measured, and the homeostasis model assessment of insulin resistance was calculated. Fat mass was calculated using a bioimpedance analysis device, and ultrasonography was performed to measure fat thickness and to detect fatty change of the liver. Results: Total leukocyte and monocyte counts were significantly increased in obese young adults. Total leukocyte count was associated with liver enzyme levels, insulin resistance as well as visceral and subcutaneous fat thickness. Neutrophil count was associated with insulin resistance. Lymphocyte count was associated with serum liver enzymes, insulin resistance, and dyslipidemia. Monocyte count was associated with serum liver enzyme, insulin resistance, visceral and subcutaneous fat thickness, body fat mass, and percentage body fat. Conclusion: The results of this study suggest that chronic low-grade systemic inflammation is associated with obesity-related complications such as nonalcoholic fatty liver disease, insulin resistance, and dyslipidemia in young adults. (C) 2015 S. Karger GmbH, Freiburg
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大西 俊介

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