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Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep

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Title: Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep
Authors: Tamura, Tomokazu Browse this author
Mine, Junki Browse this author
Torii, Shiho Browse this author
Fujimoto, Yuri Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: border disease virus
host
pathogenicity
sheep
Issue Date: Mar-2015
Publisher: The Journal of Veterinary Medical Science
Journal Title: Journal of veterinary medical science
Volume: 77
Issue: 3
Start Page: 341
End Page: 343
Publisher DOI: 10.1292/jvms.14-0434
Abstract: A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.
Rights: http://creativecommons.org/licenses/by-nc-nd/3.0/
Type: article
URI: http://hdl.handle.net/2115/59104
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田村 友和

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