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Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering

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Title: Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering
Authors: Nishida, Erika Browse this author
Miyaji, Hirofumi Browse this author →KAKEN DB
Takita, Hiroko Browse this author →KAKEN DB
Kanayama, Izumi Browse this author
Tsuji, Maiko Browse this author
Akasaka, Tsukasa Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Sakagami, Ryuji Browse this author →KAKEN DB
Kawanami, Masamitsu Browse this author →KAKEN DB
Issue Date: Jun-2014
Publisher: The Japan Society of Applied Physics
Journal Title: Japanese Journal of Applied Physics
Volume: 53
Issue: 6S
Start Page: 06JD04
Publisher DOI: 10.7567/JJAP.53.06JD04
Abstract: Carbon-based nanomaterials are being investigated for biomedical applications. Graphene oxide (GO), a monolayer of carbon, holds promise as a tissue engineering substrate due to its unique physicochemical properties. The aim of this study was to evaluate the effect of a GO coating on cell proliferation and differentiation in vitro. We also assessed the bioactivities of collagen scaffolds coated with different concentrations of GO in rats. The results showed that GO affects both cell proliferation and differentiation, and improves the properties of collagen scaffolds. Subcutaneous implant tests showed that low concentrations of GO scaffold enhances cell in-growth and is highly biodegradable, whereas high concentrations of GO coating resulted in adverse biological effects. Consequently, scaffolds modified with a suitable concentration of GO are useful as a bioactive material for tissue engineering.
Rights: © 2014 The Japan Society of Applied Physics
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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