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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
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Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering
| Title: | Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering |
| Authors: | Nishida, Erika Browse this author | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Takita, Hiroko Browse this author →KAKEN DB | | Kanayama, Izumi Browse this author | | Tsuji, Maiko Browse this author | | Akasaka, Tsukasa Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB | | Sakagami, Ryuji Browse this author →KAKEN DB | | Kawanami, Masamitsu Browse this author →KAKEN DB |
| Issue Date: | Jun-2014 |
| Publisher: | The Japan Society of Applied Physics | | 応用物理学会 |
| Journal Title: | Japanese Journal of Applied Physics |
| Volume: | 53 |
| Issue: | 6S |
| Start Page: | 06JD04 |
| Publisher DOI: | 10.7567/JJAP.53.06JD04 |
| Abstract: | Carbon-based nanomaterials are being investigated for biomedical applications. Graphene oxide (GO), a monolayer of carbon, holds promise as a tissue engineering substrate due to its unique physicochemical properties. The aim of this study was to evaluate the effect of a GO coating on cell proliferation and differentiation in vitro. We also assessed the bioactivities of collagen scaffolds coated with different concentrations of GO in rats. The results showed that GO affects both cell proliferation and differentiation, and improves the properties of collagen scaffolds. Subcutaneous implant tests showed that low concentrations of GO scaffold enhances cell in-growth and is highly biodegradable, whereas high concentrations of GO coating resulted in adverse biological effects. Consequently, scaffolds modified with a suitable concentration of GO are useful as a bioactive material for tissue engineering. |
| Rights: | © 2014 The Japan Society of Applied Physics |
| Relation: | http://iopscience.iop.org/1347-4065/53/6S |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/59234 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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