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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

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Title: Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Authors: Ishihara, Seiichiro Browse this author
Yasuda, Motoaki Browse this author
Ishizu, Akihiro Browse this author
Ishikawa, Masayori Browse this author
Shirato, Hiroki Browse this author
Haga, Hisashi Browse this author →KAKEN DB
Keywords: Activating transcription factor 5
cell growth
cell invasion
cancer cells
Issue Date: 10-Mar-2015
Publisher: Impact Journals
Journal Title: Oncotarget
Volume: 6
Issue: 7
Start Page: 4602
End Page: 4614
PMID: 25682872
Abstract: Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not known how cancer cells survive and generate malignant tumors after irradiation. Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation. In the G1-S phase of the cell cycle, cancer cells express high levels of ATF5, which promotes cell cycle progression and thereby increases radioresistance. Furthermore, ATF5 increases malignant phenotypes, such as cell growth and invasiveness, in cancer cells in vitro and in vivo. We have identified a new mechanism for the regeneration of highly malignant tumors after irradiation and shown that ATF5 plays a key role in the process.
Type: article
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 芳賀 永

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