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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Life Science / Faculty of Advanced Life Science >
Peer-reviewed Journal Articles, etc >
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
This item is licensed under:Creative Commons Attribution 3.0 Unported
| Title: | Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells |
| Authors: | Ishihara, Seiichiro Browse this author | | Yasuda, Motoaki Browse this author | | Ishizu, Akihiro Browse this author | | Ishikawa, Masayori Browse this author | | Shirato, Hiroki Browse this author | | Haga, Hisashi Browse this author →KAKEN DB |
| Keywords: | Activating transcription factor 5 | | radioresistance | | cell growth | | cell invasion | | cancer cells |
| Issue Date: | 10-Mar-2015 |
| Publisher: | Impact Journals |
| Journal Title: | Oncotarget |
| Volume: | 6 |
| Issue: | 7 |
| Start Page: | 4602 |
| End Page: | 4614 |
| PMID: | 25682872 |
| Abstract: | Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not known how cancer cells survive and generate malignant tumors after irradiation. Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation. In the G1-S phase of the cell cycle, cancer cells express high levels of ATF5, which promotes cell cycle progression and thereby increases radioresistance. Furthermore, ATF5 increases malignant phenotypes, such as cell growth and invasiveness, in cancer cells in vitro and in vivo. We have identified a new mechanism for the regeneration of highly malignant tumors after irradiation and shown that ATF5 plays a key role in the process. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/59278 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 芳賀 永
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