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Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients

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Title: Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients
Authors: Nagai, Katsura Browse this author →KAKEN DB
Makita, Hironi Browse this author →KAKEN DB
Suzuki, Masaru Browse this author →KAKEN DB
Shimizu, Kaoruko Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: annual change
forced expiratory volume in 1 second
SGRQ
smoking
exacerbation
Issue Date: Apr-2015
Publisher: Dove Medical Press
Journal Title: International journal of chronic obstructive pulmonary disease
Volume: 10
Issue: 1
Start Page: 745
End Page: 757
Publisher DOI: 10.2147/COPD.S77586
Abstract: Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on Delta FEV1/year. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, Delta FEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement. Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.
Rights: http://creativecommons.org/licenses/by-nc/3.0/
Type: article
URI: http://hdl.handle.net/2115/59284
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西村 正治

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