Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin
Title: | A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin |
Authors: | Hasebe, Akira Browse this author →KAKEN DB | Mu, Hong-Hua Browse this author | Cole, Barry C Browse this author |
Keywords: | Adhesin | TLR2 | genital mycoplasmosis | macrophage |
Issue Date: | 17-Jun-2014 |
Publisher: | Wiley-Blackwell |
Journal Title: | American Journal of Reproductive Immunology |
Volume: | 72 |
Issue: | 3 |
Start Page: | 285 |
End Page: | 295 |
Publisher DOI: | 10.1111/aji.12279 |
PMID: | 24938999 |
Abstract: | PROBLEM: Mycoplasma hominis has been implicated in many inflammatory conditions of the human urogenital tract in particular amniotic infections that lead to fetal and neonatal disease and pre-term labor. The mechanisms responsible are poorly defined. METHOD OF STUDY: Biochemical and immunological methods were used to extract, purify, and characterize an inflammatory component present in M. hominis. RESULTS: We isolated and purified to homogeneity a 40-kDa bioactive lipoprotein from M. hominis that was a potent TLR2-dependent, CD14-independent activator of the human THP-1 macrophage cell line. Homology searches of the N-terminal sequence revealed that 22 of the first 23 residues were identical to those seen for the phase-variable M. hominis p50 adhesin. The truncated P50t lipoprotein importantly retained its adhesive properties for human macrophages. CONCLUSION: The unique adhesin/macrophage activator may play a key role in M. hominis infections by triggering an inflammatory cytokine cascade. |
Rights: | This is the pre-peer-reviewed version of the following article: FULL CITE, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/aji.12279/abstract;jsessionid=500DAAEB7BE065A3A9874F78C851B78C.f01t02 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/59366 |
Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 長谷部 晃
|