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A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/59366

Title: A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin
Authors: Hasebe, Akira Browse this author →KAKEN DB
Mu, Hong-Hua Browse this author
Cole, Barry C Browse this author
Keywords: Adhesin
TLR2
genital mycoplasmosis
macrophage
Issue Date: 17-Jun-2014
Publisher: Wiley-Blackwell
Journal Title: American Journal of Reproductive Immunology
Volume: Epub ahead of print
Publisher DOI: 10.1111/aji.12279
PMID: 24938999
Abstract: PROBLEM: Mycoplasma hominis has been implicated in many inflammatory conditions of the human urogenital tract in particular amniotic infections that lead to fetal and neonatal disease and pre-term labor. The mechanisms responsible are poorly defined. METHOD OF STUDY: Biochemical and immunological methods were used to extract, purify, and characterize an inflammatory component present in M. hominis. RESULTS: We isolated and purified to homogeneity a 40-kDa bioactive lipoprotein from M. hominis that was a potent TLR2-dependent, CD14-independent activator of the human THP-1 macrophage cell line. Homology searches of the N-terminal sequence revealed that 22 of the first 23 residues were identical to those seen for the phase-variable M. hominis p50 adhesin. The truncated P50t lipoprotein importantly retained its adhesive properties for human macrophages. CONCLUSION: The unique adhesin/macrophage activator may play a key role in M. hominis infections by triggering an inflammatory cytokine cascade.
Rights: This is the pre-peer-reviewed version of the following article: FULL CITE, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/aji.12279/abstract;jsessionid=500DAAEB7BE065A3A9874F78C851B78C.f01t02
Type: article (author version)
URI: http://hdl.handle.net/2115/59366
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷部 晃

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