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Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors
Title: | Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors |
Authors: | Sato, Shoki Browse this author | Tsuchikawa, Takahiro Browse this author | Nakamura, Toru Browse this author | Sato, Nagato Browse this author | Tamoto, Eiji Browse this author | Okamura, Keisuke Browse this author | Shichinohe, Toshiaki Browse this author →KAKEN DB | Hirano, Satoshi Browse this author →KAKEN DB |
Keywords: | pancreatic neuroendocrine tumor | postoperative hepatic recurrence | tumor-infiltrating lymphocytes | ATRX/DAXX | p-mTOR |
Issue Date: | Dec-2014 |
Publisher: | Spandidos Publications |
Journal Title: | Oncology reports |
Volume: | 32 |
Issue: | 6 |
Start Page: | 2753 |
End Page: | 2759 |
Publisher DOI: | 10.3892/or.2014.3530 |
PMID: | 25310565 |
Abstract: | The disease frequency of pancreatic neuroendocrine tumors (PNETs) has been growing, and postoperative hepatic recurrence (PHR) is one of the factors affecting patient prognosis. The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PHR using immunohistochemical analysis for tumor-infiltrating lymphocytes (TILs: CD3, CD8 and CD45RO), human leukocyte antigen (HLA) class I, alpha-thalassemia/mental retardation X-linked (ATRX), death domain-associated protein (DAXX), mammalian target of rapamycin (mTOR) and phospho-mTOR (p-mTOR). Correlations were analyzed between TILs and the biomarkers, clinicopathological features and prognosis. Sixteen patients with PNETs who underwent radical surgery at our hospital were reviewed. We analyzed the correlation between PHR and immunohistochemical characteristics, and also between disease-free survival (DFS) or overall survival (OS) and the immunohistochemical characteristics. We found that PHR was associated with the expression patterns of DAXX and p-mTOR. No association was found between PHR and patient background, TILs or other biomarkers. DFS was found to be associated with ATRX, DAXX and p-mTOR. OS was associated only with p-mTOR. In conclusion, ATRX, DAXX and p-mTOR are useful molecular biomarkers for predicting PHR in patients who undergo radical surgery for PNETs. Use of these biomarkers will enable earlier decisions on which patients may benefit from adjuvant therapy. |
Type: | article |
URI: | http://hdl.handle.net/2115/59434 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 彰記
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