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Manipulation of Object Choice by Electrical Microstimulation in Macaque Frontal Eye Fields

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Title: Manipulation of Object Choice by Electrical Microstimulation in Macaque Frontal Eye Fields
Authors: Matsushima, Ayano Browse this author
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: Eye movement
Object selection
Primate
Single-unit recording
Target selection
Issue Date: Jun-2014
Publisher: Oxford University Press
Journal Title: Cerebral cortex
Volume: 24
Issue: 6
Start Page: 1493
End Page: 1501
Publisher DOI: 10.1093/cercor/bht009
PMID: 23349221
Abstract: For each saccade, we select an object to direct gaze and to specify the direction and amplitude of eye movement. Although these 2 processes are inevitably interdependent when visual stimuli are held stationary, several lines of evidence suggest that the neuronal signals in the frontal eye fields (FEF) that underlie the selection of visual objects are distinct from those underlying the selection of saccades. In the present study, we overtly dissociated these 2 processes spatially and temporally using the covert object-tracking paradigm, in which 4 identical objects moved randomly for 3 s before monkeys made a saccade to a previously selected target. To assess the causal role of the FEF in the 2 selection processes, we applied electrical microstimulation to the FEF at various times during the motion period. When stimulation was delivered at the motion onset, animals tended to choose an object that was initially presented at a particular location depending on the stimulation site. In contrast, the same stimulation delivered at the motion end failed to alter saccade end points. These results indicate that manipulation of FEF activity can change the selection of a visual object without affecting saccade goals, suggesting the existence of neurons solely regulating visual selection.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in "Cerebral Cortex" following peer review. The definitive publisher-authenticated version [Matsushima A, Tanaka M (2014a) Manipulation of object choice by electrical microstimulation in macaque frontal eye fields. Cereb Cortex 24:1493–1501] is available online at: http://dx.doi.org/10.1093/cercor/bht009
Type: article (author version)
URI: http://hdl.handle.net/2115/59435
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 真樹

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