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Risk of cerebral palsy associated with neonatal encephalopathy in macrosomic neonates

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Title: Risk of cerebral palsy associated with neonatal encephalopathy in macrosomic neonates
Authors: Yamada, Takahiro Browse this author →KAKEN DB
Akaishi, Rina Browse this author
Yamada, Takashi Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Kaneuchi, Masanori Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: cerebral palsy
diabetes mellitus
gestational hypoxic encephalopathy
macrosomia
Issue Date: Jun-2014
Publisher: Wiley-Blackwell
Journal Title: Journal of Obstetrics and Gynaecology Research
Volume: 40
Issue: 6
Start Page: 1611
End Page: 1617
Publisher DOI: 10.1111/jog.12367
PMID: 24888924
Abstract: Aim To determine whether macrosomic infants with a birthweight of 4.0kg or more have increased risk of cerebral palsy associated with neonatal encephalopathy (Enc-CP). Methods A retrospective review of 132 singleton infants with Enc-CP fulfilling all of the following criteria: born at gestational week (GW) 37 or more (n=126) or weighing 2.5kg or more at birth (n=116) in or after January 2009 in Japan; no identifiable causes of cerebral palsy other than antenatal or intrapartum hypoxia; and exhibition of neonatal encephalopathy. National statistics of Japan were used to determine the numbers of infants according to birthweight categories. Results Of the 116 infants with a birthweight of 2.5kg or more, 46 (39.7%), 49 (42.2%), 17 (14.7%) and four (3.4%) infants had birthweights of 2.5-2.99, 3.0-3.49, 3.5-3.99 and 4.0kg or more, respectively. Corresponding figures among Japanese infants born in 2009-2011 were 42.8%, 45.4%, 10.9% and 0.90%, respectively. Infants with a birthweight of 4.0kg or more had a relative risk (95% confidence interval) of Enc-CP of 3.89 (1.52-9.95) compared to those with a birthweight of 2.5-2.99kg. Conclusion Japanese infants with a birthweight of 4.0kg or more have increased risk of Enc-CP.
Rights: The definitive version is available at Wiley Online Library, www.wileyonlinelibrary.com.
Type: article (author version)
URI: http://hdl.handle.net/2115/59436
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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