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Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with O-15-H2O PET

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/59526

Title: Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with O-15-H2O PET
Authors: Kikuchi, Yasuka Browse this author
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Naya, Masanao Browse this author →KAKEN DB
Manabe, Osamu Browse this author
Tomiyama, Yuuki Browse this author
Sasaki, Tsukasa Browse this author
Katoh, Chietsugu Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: MDCT
Cardiac
Perfusion
Myocardium blood flow
Coronary flow reserve
Issue Date: Jul-2014
Publisher: Springer
Journal Title: European Radiology
Volume: 24
Issue: 7
Start Page: 1547
End Page: 1556
Publisher DOI: 10.1007/s00330-014-3164-3
PMID: 24744200
Abstract: This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against O-15-H2O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients. Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7). Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 +/- 0.8) was significantly lower than that in the validation group (5.2 +/- 1.8) (P = 0.0011). We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP. aEuro cent MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. aEuro cent MBF and CFR showed good correlation between dynamic CTP and PET. aEuro cent Lower CFR was well demonstrated in CAD patients by dynamic CTP.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/59526
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 菊池 穏香

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