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Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells

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Title: Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells
Authors: Sun, Yongkun Browse this author
Liu, Chuang Browse this author
Liu, Yutong Browse this author
Hosokawa, Toshiyuki Browse this author →KAKEN DB
Saito, Takeshi Browse this author →KAKEN DB
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: epigenetic
Sir2
DNA methylation
Copper
oxidative stress
Issue Date: 29-Jul-2014
Publisher: Taylor & Francis
Journal Title: Journal of Environmental Science and Health, Part A : Toxic/Hazardous Substances & Environmental Engineering
Volume: 49
Issue: 9
Start Page: 1023
End Page: 1028
Publisher DOI: 10.1080/10934529.2014.894847
PMID: 24798901
Abstract: Despite extensive research on copper toxicity the mechanisms involved are not fully characterized. There have been many recent reports concerning the relationship between epigenetic factors and cell metabolism, but the effects of copper exposure on epigenetic factors have not been investigated. In this study, an in vitro culture system was employed to study the influence of copper on apoptosis and epigenetic factors in PC12 cells. When PC12 cells were exposed to copper, DNA damage was observed as DNA fragmentation. In addition, cytosolic cytochrome c levels were increased by copper treatment. These results suggested that copper induced apoptosis via an oxidative stress pathway. This was consistent with the observation that copper-induced apoptosis was enhanced by further oxidative stress induced by exposing cells to H2O2. In addition, the epigenetic factors were significantly increased in apoptotic cells following exposure to copper and oxidative stress.
Rights: This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part A, Toxic/hazardous substances & environmental engineering, Vol. 49, Iss. 9, 2014, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/10934529.2014.894847.
Type: article (author version)
URI: http://hdl.handle.net/2115/59555
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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