HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum : A Study Using a High-Resolution Semiconductor PET System

Files in This Item:
1206.full.pdf839.37 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/59592

Title: Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum : A Study Using a High-Resolution Semiconductor PET System
Authors: Hirata, Kenji Browse this author →KAKEN DB
Hattori, Naoya Browse this author
Takeuchi, Wataru Browse this author
Shiga, Tohru Browse this author
Morimoto, Yuichi Browse this author
Umegaki, Kikuo Browse this author
Kobayashi, Kentaro Browse this author
Manabe, Osamu Browse this author →KAKEN DB
Okamoto, Shozo Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: red nucleus
semiconductor detector
18F-FDG PET
voxel-based analysis
metabolic correlation
Issue Date: 1-Aug-2015
Publisher: Society of Nuclear Medicine and Molecular Imaging
Journal Title: Journal of Nuclear Medicine
Volume: 56
Issue: 8
Start Page: 1206
End Page: 1211
Publisher DOI: 10.2967/jnumed.114.152504
PMID: 26045313
Abstract: The red nucleus (RN) is a pair of small gray matter structures located in the midbrain and involved in muscle movement and cognitive functions. This retrospective study aimed to investigate the metabolism of human RN and its correlation to other brain regions. Methods: We developed a high-resolution semiconductor PET system to image small brain structures. Twenty patients without neurologic disorders underwent whole-brain scanning after injection of 400 MBq of 18F-FDG. The individual brain 18F-FDG PET images were spatially normalized to generate a surface projection map using a 3-dimensional stereotactic surface projection technique. The correlation between the RN and each voxel on the cerebral and cerebellar cortices was estimated with Pearson product-moment correlation analysis. Results: Both right and left RNs were visualized with higher uptake than that in the background midbrain. The maximum standardized uptake values of RN were 7.64 ± 1.92; these were higher than the values for the dentate nucleus but lower than those for the caudate nucleus, putamen, and thalamus. The voxel-by-voxel analysis demonstrated that the right RN was correlated more with ipsilateral association cortices than contralateral cortices, whereas the left RN was equally correlated with ipsilateral and contralateral cortices. The left RN showed a stronger correlation with the motor cortices and cerebellum than the right RN did. Conclusion: Although nonspecific background activity around RNs might have influenced the correlation patterns, these metabolic relationships suggested that RN cooperates with association cortices and limbic areas to conduct higher brain functions.
Rights: This research was originally published in JNM. Kenji Hirata, et al. Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum. JNM. 2015;56(8):pp.1206-1211. © by the Society of Nuclear Medicine and Molecular Imaging, Inc.
Type: article
URI: http://hdl.handle.net/2115/59592
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University