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DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
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| Title: | DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation |
| Authors: | Oshiumi, Hiroyuki Browse this author →KAKEN DB | | Miyashita, Moeko Browse this author | | Okamoto, Masaaki Browse this author | | Morioka, Yuka Browse this author →KAKEN DB | | Okabe, Masaru Browse this author →KAKEN DB | | Matsumoto, Misako Browse this author →KAKEN DB | | Seya, Tsukasa Browse this author →KAKEN DB |
| Issue Date: | 26-May-2015 |
| Publisher: | Cell Press |
| Journal Title: | Cell reports |
| Volume: | 11 |
| Issue: | 8 |
| Start Page: | 1193 |
| End Page: | 1207 |
| Publisher DOI: | 10.1016/j.celrep.2015.04.047 |
| PMID: | 25981042 |
| Abstract: | RIG-I-mediated type I interferon (IFN) production and nuclease-mediated viral RNA degradation are essential for antiviral innate immune responses. DDX60 is an IFN-inducible cytoplasmic helicase. Here, we report that DDX60 is a sentinel for both RIG-I activation and viral RNA degradation. We show that DDX60 is an upstream factor of RIG-I that activates RIG-I signaling in a ligand-specific manner. DDX60 knockout attenuates RIG-I signaling and significantly reduces virus-induced type I IFN production in vivo. In addition, we show that DDX60 is involved in RIG-I-independent viral RNA degradation. DDX60 and RIG-I adaptor MAVS double-knockout mice reveal a role for DDX60-dependent RNA degradation in antiviral responses. Several viruses induced DDX60 phosphorylation via epidermal growth factor receptor (EGFR), leading to attenuation of the DDX60 antiviral activities. Our results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/59596 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 押海 裕之
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