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Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva

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J.Epidemiol2015.25(7).470-474.pdf429.72 kBPDFView/Open
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Title: Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva
Authors: Oikawa, Junko Browse this author
Ukawa, Shigekazu Browse this author →KAKEN DB
Ohira, Hideki Browse this author →KAKEN DB
Kawamura, Takashi Browse this author →KAKEN DB
Wakai, Kenji Browse this author
Ando, Masahiko Browse this author
Hata, Akira Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: diabetes mellitus
secretory immunoglobulin A
Issue Date: Jul-2015
Publisher: 日本疫学会
Journal Title: Journal of epidemiology
Volume: 25
Issue: 7
Start Page: 470
End Page: 474
Publisher DOI: 10.2188/jea.JE20140088
Abstract: Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people. Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status. Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 mu g/min vs 15.0 mu g/min, P = 0.03), even after elimination of the effects of possible confounders. Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川 純子

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