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The diagnostic role of F-18-FDG PET for primary central nervous system lymphoma

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タイトル: The diagnostic role of F-18-FDG PET for primary central nervous system lymphoma
著者: Yamaguchi, Shigeru 著作を一覧する
Hirata, Kenji 著作を一覧する
Kobayashi, Hiroyuki 著作を一覧する
Shiga, Tohru 著作を一覧する
Manabe, Osamu 著作を一覧する
Kobayashi, Kentaro 著作を一覧する
Motegi, Hiroaki 著作を一覧する
Terasaka, Shunsuke 著作を一覧する
Houkin, Kiyohiro 著作を一覧する
キーワード: Brain tumor
Primary central nervous system lymphoma
ROC curve
発行日: 2014年 8月
出版者: Springer
誌名: Annals of Nuclear Medicine
巻: 28
号: 7
開始ページ: 603
終了ページ: 609
出版社 DOI: 10.1007/s12149-014-0851-8
抄録: F-18-FDG PET has become one of the most important methods for studying malignant lymphoma, but its diagnostic role for primary central nervous system lymphoma (PCNSL) has not been established. The aim of this study was to determine the appropriate cut-off values of FDG uptake and to investigate how corticosteroid administration influences PCNSL. We retrospectively reviewed 82 patients with contrast-enhanced brain tumors who underwent an FDG PET scan at onset, including 19 PCNSLs. FDG uptake of the lesion was assessed by the maximum standardized uptake value (SUVmax) and the ratio of tumor to normal contralateral cortex activity (T/N ratio). Receiver operating characteristic (ROC) curves were generated from the SUVmax and T/N ratios. To investigate the influence of corticosteroid application before a FDG PET scan, we evaluated the association between the FDG uptake of the lesion and the cumulative dose of corticosteroid administration on 13 PCNSL patients who had received steroid treatment before an FDG PET examination. The mean FDG SUVmax and T/N ratio of PCNSLs were 22.6 and 2.79, respectively, and these values were significantly higher than those of the other malignant brain tumors. ROC analysis indicated that the evaluation of FDG uptake using the T/N ratio was more reliable than the SUVmax with respect to the differential diagnosis. When PCNSL patients went without steroid application before FDG PET, the accuracy of the T/N ratio with a cut-off point of 2.0 was 91.1 %, the sensitivity was 94.7 %, and the specificity was 87.3 %. Although there are no significant differences in the FDG T/N ratio for PCNSL patients with or without steroid treatment, a negative correlation was found between the T/N ratio and cumulative dose of corticosteroid before PET study (r = -0.71, p = 0.032). We concluded that the T/N ratio was superior to SUVmax for FDG uptake assessment as for distinguishing PCNSLs from other malignant brain tumors; the appropriate T/N ratio cut-off point was 2.0. In addition, FDG uptake could be influenced by cumulative doses of corticosteroid before a PET scan, and thus this fact should be taken into consideration when evaluating FDG PET for PCNSL diagnosis.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 寺坂 俊介


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