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Survival of rabid rabbits after intrathecal immunization

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Title: Survival of rabid rabbits after intrathecal immunization
Authors: Kesdangsakonwut, Sawang Browse this author
Sunden, Yuji Browse this author →KAKEN DB
Aoshima, Keisuke Browse this author
Iwaki, Yoshimi Browse this author
Okumura, Masahiro Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Umemura, Takashi Browse this author →KAKEN DB
Keywords: animal experiment
CNS pathology
intrathecal immunization
rabies virus
treatment of rabies
Issue Date: Jun-2014
Publisher: Wiley-Blackwell
Journal Title: Neuropathology
Volume: 34
Issue: 3
Start Page: 277
End Page: 283
Publisher DOI: 10.1111/neup.12094
Abstract: Rabies is a fatal zoonotic disease for which no effective treatment measures are currently available. Rabies virus (RABV) has anti-apoptotic and anti-inflammatory properties that suppress nerve cell damage and inflammation in the CNS. These features imply that the elimination of RABV from the CNS by appropriate treatment could lead to complete recovery from rabies. Ten rabbits showing neuromuscular symptoms of rabies after subcutaneous (SC) immunization using commercially available vaccine containing inactivated whole RABV particles and subsequent fixed RABV (CVS strain) inoculation into hind limb muscles were allocated into three groups. Three rabbits received no further treatment (the SC group), three rabbits received three additional SC immunizations using the same vaccine, and four rabbits received three intrathecal (IT) immunizations, in which the vaccine was inoculated directly into the cerebrospinal fluid (the SC/IT group). An additional three naïve rabbits were inoculated intramuscularly with RABV and not vaccinated. The rabbits exhibited neuromuscular symptoms of rabies within 4-8 days post-inoculation (dpi) of RABV. All of the rabbits died within 8-12 dpi with the exception of one rabbit in the SC group and all four rabbits in SC/IT group, which recovered and started to respond to external stimuli at 11-18 dpi and survived until the end of the experimental period. RABV was eliminated from the CNS of the surviving rabbits. We report here a possible, although still incomplete, therapy for rabies using IT immunization. Our protocol may rescue the life of rabid patients and prompt the future development of novel therapies against rabies.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 梅村 孝司

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