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Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice

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タイトル: Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
著者: Kase, Satoru 著作を一覧する
Yoshida, Kazuhiko 著作を一覧する
Sakai, Masaharu 著作を一覧する
Ohgami, Kazuhiro 著作を一覧する
Shiratori, Kenji 著作を一覧する
Kitaichi, Nobuyoshi 著作を一覧する
Suzuki, Yukari 著作を一覧する
Harada, Takayuki 著作を一覧する
Ohno, Shigeaki 著作を一覧する
キーワード: C-maf
Cyclin D1
発行日: 2006年 2月20日
出版者: Elsevier
誌名: Acta Histochemica
巻: 107
号: 6
開始ページ: 469
終了ページ: 472
出版社 DOI: 10.1016/j.acthis.2005.10.002
抄録: The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf family genes have important roles in embryonic development and cellular differentiation. In this study, localization of cyclin D1, one of the cell cycle-related molecules, was examined immunohistochemically in developing lens cells of c-maf knockout (-/-) mice. At embryonic day 14 in wild-type mice, lens cells consisted of round epithelial cells in a single layer and regularly arranged elongated lens cells, indicating primary lens fiber cells. Cyclin D1-positive nuclei were observed in the lens epithelial cells, whereas cyclin D1 was not detected in the primary lens fiber cells. In c-maf -/- mice, a variety of round epithelial cells were located in the anterior and posterior lens. Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加瀬 諭


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