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Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
| Title: | Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice |
| Authors: | Kase, Satoru1 Browse this author →KAKEN DB | | Yoshida, Kazuhiko Browse this author →KAKEN DB | | Sakai, Masaharu Browse this author →KAKEN DB | | Ohgami, Kazuhiro Browse this author →KAKEN DB | | Shiratori, Kenji Browse this author | | Kitaichi, Nobuyoshi Browse this author →KAKEN DB | | Suzuki, Yukari Browse this author | | Harada, Takayuki Browse this author | | Ohno, Shigeaki Browse this author →KAKEN DB |
| Authors(alt): | 加瀬, 諭1 |
| Keywords: | C-maf | | Cyclin D1 | | Lens | | Immunohistochemistry |
| Issue Date: | 20-Feb-2006 |
| Publisher: | Elsevier |
| Journal Title: | Acta Histochemica |
| Volume: | 107 |
| Issue: | 6 |
| Start Page: | 469 |
| End Page: | 472 |
| Publisher DOI: | 10.1016/j.acthis.2005.10.002 |
| PMID: | 16325892 |
| Abstract: | The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf family genes have important roles in embryonic development and cellular differentiation. In this study, localization of cyclin D1, one of the cell cycle-related molecules, was examined immunohistochemically in developing lens cells of c-maf knockout (-/-) mice. At embryonic day 14 in wild-type mice, lens cells consisted of round epithelial cells in a single layer and regularly arranged elongated lens cells, indicating primary lens fiber cells. Cyclin D1-positive nuclei were observed in the lens epithelial cells, whereas cyclin D1 was not detected in the primary lens fiber cells. In c-maf -/- mice, a variety of round epithelial cells were located in the anterior and posterior lens. Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells. |
| Relation: | http://www.sciencedirect.com/science/journal/00651281 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/5980 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加瀬 諭
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