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Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice

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Title: Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
Authors: Kase, Satoru1 Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Sakai, Masaharu Browse this author →KAKEN DB
Ohgami, Kazuhiro Browse this author →KAKEN DB
Shiratori, Kenji Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Suzuki, Yukari Browse this author
Harada, Takayuki Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Authors(alt): 加瀬, 諭1
Keywords: C-maf
Cyclin D1
Issue Date: 20-Feb-2006
Publisher: Elsevier
Journal Title: Acta Histochemica
Volume: 107
Issue: 6
Start Page: 469
End Page: 472
Publisher DOI: 10.1016/j.acthis.2005.10.002
PMID: 16325892
Abstract: The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf family genes have important roles in embryonic development and cellular differentiation. In this study, localization of cyclin D1, one of the cell cycle-related molecules, was examined immunohistochemically in developing lens cells of c-maf knockout (-/-) mice. At embryonic day 14 in wild-type mice, lens cells consisted of round epithelial cells in a single layer and regularly arranged elongated lens cells, indicating primary lens fiber cells. Cyclin D1-positive nuclei were observed in the lens epithelial cells, whereas cyclin D1 was not detected in the primary lens fiber cells. In c-maf -/- mice, a variety of round epithelial cells were located in the anterior and posterior lens. Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加瀬 諭

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