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Hokkaido University Collection of Scholarly and Academic Papers >
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α-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves
| Title: | α-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves |
| Authors: | Yonemoto, Ryuta Browse this author | | Shimada, Miyuki Browse this author | | Gunawan-Puteri, Maria D. P. T. Browse this author | | Kato, Eisuke Browse this author →KAKEN DB | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Abrus precatorius | | α-amylase inhibitor | | triterpene ketone |
| Issue Date: | Aug-2014 |
| Publisher: | American Chemical Society |
| Journal Title: | Journal of Agricultural and Food Chemistry |
| Volume: | 62 |
| Issue: | 33 |
| Start Page: | 8411 |
| End Page: | 8414 |
| Publisher DOI: | 10.1021/jf502667z |
| PMID: | 25089582 |
| Abstract: | In the screening experiments for porcine pancreatic α-amylase inhibitors in 18 plants obtained from Indonesia, a potent inhibitory activity was detected in the extract of leaves of Abrus precatorius. The enzyme assay-guided fractionation of the extract led to the isolation of a triterpene ketone, lupenone (1), as a potent α-amylase inhibitor, together with 24- methylenecycloartenone (2) and luteolin (3). The mode of inhibition of compound 1 against porcine pancreatic α -amylase was a mixed inhibition. This is the first report that describes the potent α -amylase inhibitory activity of the low-polar triterpene ketone similar to compound 1. A comparison of the activities of the isolate and related compounds indicated the importance of C-3 ketone and the lupane skeleton in the α -amylase inhibitory activity. |
| Rights: | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/pdf/10.1021/jf502667z, see http://pubs.acs.org/page/policy/articlesonrequest/index.html. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/59806 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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