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α-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves

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Title: α-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves
Authors: Yonemoto, Ryuta Browse this author
Shimada, Miyuki Browse this author
Gunawan-Puteri, Maria D. P. T. Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Abrus precatorius
α-amylase inhibitor
triterpene ketone
Issue Date: Aug-2014
Publisher: American Chemical Society
Journal Title: Journal of Agricultural and Food Chemistry
Volume: 62
Issue: 33
Start Page: 8411
End Page: 8414
Publisher DOI: 10.1021/jf502667z
PMID: 25089582
Abstract: In the screening experiments for porcine pancreatic α-amylase inhibitors in 18 plants obtained from Indonesia, a potent inhibitory activity was detected in the extract of leaves of Abrus precatorius. The enzyme assay-guided fractionation of the extract led to the isolation of a triterpene ketone, lupenone (1), as a potent α-amylase inhibitor, together with 24- methylenecycloartenone (2) and luteolin (3). The mode of inhibition of compound 1 against porcine pancreatic α -amylase was a mixed inhibition. This is the first report that describes the potent α -amylase inhibitory activity of the low-polar triterpene ketone similar to compound 1. A comparison of the activities of the isolate and related compounds indicated the importance of C-3 ketone and the lupane skeleton in the α -amylase inhibitory activity.
Rights: This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see, see
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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