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Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/59811

Title: Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity
Authors: Fukae, Jun Browse this author
Isobe, Masato Browse this author
Kitano, Akemi Browse this author
Henmi, Mihoko Browse this author
Sakamoto, Fumihiko Browse this author
Narita, Akihiro Browse this author
Ito, Takeya Browse this author
Mitsuzaki, Akio Browse this author
Shimizu, Masato Browse this author
Tanimura, Kazuhide Browse this author
Matsuhashi, Megumi Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Koike, Takao Browse this author →KAKEN DB
Keywords: rheumatoid arthritis
ultrasonography
power Doppler
clinical remission
treat to target
Issue Date: Sep-2014
Publisher: Oxford University Press
Journal Title: Rheumatology
Volume: 53
Issue: 9
Start Page: 1608
End Page: 1612
Publisher DOI: 10.1093/rheumatology/keu154
PMID: 24706991
Abstract: Objective. In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA). Methods. RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks). Results. Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period. Conclusion. Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
Rights: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record "Jun Fukae, Masato Isobe, Akemi Kitano, et al. Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity. Rheumatology (Oxford), September 1, 2014 vol. 53 no. 9, 1608-1612" is available online at: http://dx.doi.org/10.1093/rheumatology/keu154
Type: article (author version)
URI: http://hdl.handle.net/2115/59811
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 渥美 達也

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