| Title: | Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity |
| Authors: | Fukae, Jun Browse this author |
| Isobe, Masato Browse this author |
| Kitano, Akemi Browse this author |
| Henmi, Mihoko Browse this author |
| Sakamoto, Fumihiko Browse this author |
| Narita, Akihiro Browse this author |
| Ito, Takeya Browse this author |
| Mitsuzaki, Akio Browse this author |
| Shimizu, Masato Browse this author |
| Tanimura, Kazuhide Browse this author |
| Matsuhashi, Megumi Browse this author |
| Kamishima, Tamotsu Browse this author →KAKEN DB |
| Atsumi, Tatsuya Browse this author →KAKEN DB |
| Koike, Takao Browse this author →KAKEN DB |
| Keywords: | rheumatoid arthritis |
| ultrasonography |
| power Doppler |
| clinical remission |
| treat to target |
| Issue Date: | Sep-2014 |
| Publisher: | Oxford University Press |
| Journal Title: | Rheumatology |
| Volume: | 53 |
| Issue: | 9 |
| Start Page: | 1608 |
| End Page: | 1612 |
| Publisher DOI: | 10.1093/rheumatology/keu154 |
| PMID: | 24706991 |
| Abstract: | Objective. In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA). Methods. RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks). Results. Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period. Conclusion. Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN. |
| Rights: | This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record "Jun Fukae, Masato Isobe, Akemi Kitano, et al. Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity. Rheumatology (Oxford), September 1, 2014 vol. 53 no. 9, 1608-1612" is available online at: http://dx.doi.org/10.1093/rheumatology/keu154 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/59811 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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