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Multicenter study on hemorrhagic risk of heparin bridging therapy for periendoscopic thromboprophylaxis

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/59829

タイトル: Multicenter study on hemorrhagic risk of heparin bridging therapy for periendoscopic thromboprophylaxis
著者: Matsumoto, Mio 著作を一覧する
Mabe, Katsuhiro 著作を一覧する
Tsuda, Momoko 著作を一覧する
Ono, Masayoshi 著作を一覧する
Omori, Saori 著作を一覧する
Takahashi, Masakazu 著作を一覧する
Yoshida, Takeshi 著作を一覧する
Ono, Shoko 著作を一覧する
Nakagawa, Manabu 著作を一覧する
Nakagawa, Soichi 著作を一覧する
Shimizu, Yuichi 著作を一覧する
Kudo, Takahiko 著作を一覧する
Sakamoto, Naoya 著作を一覧する
Kato, Mototsugu 著作を一覧する
キーワード: Endoscopic treatment
Post-procedural bleeding
Thrombosis
Antithrombotic therapy
発行日: 2015年 7月29日
出版者: BioMed Central
誌名: BMC gastroenterology
巻: 15
開始ページ: 89
出版社 DOI: 10.1186/s12876-015-0315-1
抄録: Background: For endoscopic interventions, heparin bridging therapy is recommended in patients who are at high risk from interruption of antithrombotic therapy. Although heparin bridging has been reported to be effective in preventing thrombosis, several reports have raised concerns about increased risk of bleeding. The aim of this study was to clarify complications of hepari bridging therapy in therapeutic endoscopy. Methods: A nationwide multicenter survey using questionnaire was performed about patients undergoing therapeutic endoscopy with heparin bridging. Patients who underwent therapeutic endoscopy without heparin bridging therapy were considered as controls. Compliance scores of heparin bridging therapy guideline were employed, and association was analyzed between the score and occurrence of post-procedural bleeding. Results: The incidence of post-procedural bleeding was significantly higher (13.5 %, 33/245) in the heparin group compared with the control group (2.7 %, 299/11102)(p < 0.001). Thrombosis occurred in 1 patient each in the two groups. In the heparin group, post-procedural bleeding was more likely to be delayed bleeding. Dose adjustment of heparin was a significant factor contributing to bleeding. The compliance score of heparin bridging therapy guideline was significantly higher in those who suffered bleeding. Conclusions: Heparin bridging therapy significantly increased the risk of post-procedural bleeding compared with the control. The bleeding risk was associated with greater adherence with guidelines for heparin bridging therapy.
資料タイプ: article
URI: http://hdl.handle.net/2115/59829
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加藤 元嗣

 

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