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Isolation and characterization of a novel alphaherpesvirus in fruit bats.

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Title: Isolation and characterization of a novel alphaherpesvirus in fruit bats.
Authors: Sasaki, Michihito Browse this author →KAKEN DB
Setiyono, Agus Browse this author
Handharyani, Ekowati Browse this author
Kobayashi, Shintaro Browse this author →KAKEN DB
Rahmadani, Ibenu Browse this author
Taha, Siswatiana Browse this author
Adiani, Sri Browse this author
Subangkit, Mawar Browse this author
Nakamura, Ichiro Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Kimura, Takashi Browse this author →KAKEN DB
Issue Date: Sep-2014
Publisher: American Society for Microbiology
Journal Title: Journal of virology
Volume: 88
Issue: 17
Start Page: 9819
End Page: 9829
Publisher DOI: 10.1128/JVI.01277-14
PMID: 24942567
Abstract: Bats are known to harbor emerging RNA viruses. Recent studies have used high-throughput sequencing technology to identify various virus species, including DNA viruses that are harbored by bats; however, little is known about the nature of these potentially novel viruses. Here, we report the characterization of a novel herpesvirus isolated from an Indonesian pteropodid bat. The virus, tentatively named fruit bat alphaherpesvirus 1 (FBAHV1), has a double-stranded DNA genome of 149,459 bp. The phylogenetic analyses suggested that FBAHV1 is phylogenetically grouped with simplexviruses within the subfamily Alphaherpesvirinae. Inoculation of FBAHV1 into laboratory mice caused a lethal infection. Virus infection was observed in lung, liver, and brain tissue. Serological and PCR screening revealed that fruit bats infected with FBAHV1 or its related virus are widely distributed in Indonesia. The identification of FBAHV1 makes a considerable contribution to our understanding of simplexviruses associated with bats.
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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