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Isolation and characterization of a novel alphaherpesvirus in fruit bats.
| Title: | Isolation and characterization of a novel alphaherpesvirus in fruit bats. |
| Authors: | Sasaki, Michihito Browse this author →KAKEN DB | | Setiyono, Agus Browse this author | | Handharyani, Ekowati Browse this author | | Kobayashi, Shintaro Browse this author →KAKEN DB | | Rahmadani, Ibenu Browse this author | | Taha, Siswatiana Browse this author | | Adiani, Sri Browse this author | | Subangkit, Mawar Browse this author | | Nakamura, Ichiro Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB | | Kimura, Takashi Browse this author →KAKEN DB |
| Issue Date: | Sep-2014 |
| Publisher: | American Society for Microbiology |
| Journal Title: | Journal of virology |
| Volume: | 88 |
| Issue: | 17 |
| Start Page: | 9819 |
| End Page: | 9829 |
| Publisher DOI: | 10.1128/JVI.01277-14 |
| PMID: | 24942567 |
| Abstract: | Bats are known to harbor emerging RNA viruses. Recent studies have used high-throughput sequencing technology to identify various virus species, including DNA viruses that are harbored by bats; however, little is known about the nature of these potentially novel viruses. Here, we report the characterization of a novel herpesvirus isolated from an Indonesian pteropodid bat. The virus, tentatively named fruit bat alphaherpesvirus 1 (FBAHV1), has a double-stranded DNA genome of 149,459 bp. The phylogenetic analyses suggested that FBAHV1 is phylogenetically grouped with simplexviruses within the subfamily Alphaherpesvirinae. Inoculation of FBAHV1 into laboratory mice caused a lethal infection. Virus infection was observed in lung, liver, and brain tissue. Serological and PCR screening revealed that fruit bats infected with FBAHV1 or its related virus are widely distributed in Indonesia. The identification of FBAHV1 makes a considerable contribution to our understanding of simplexviruses associated with bats. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/59849 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐々木 道仁
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