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Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray

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Title: Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray
Authors: Nitta, T. Browse this author
Mitsuhashi, Tomoko Browse this author →KAKEN DB
Hatanaka, Y. Browse this author
Miyamoto, M. Browse this author
Oba, K. Browse this author
Tsuchikawa, T. Browse this author
Suzuki, Y. Browse this author
Hatanaka, K. C. Browse this author
Hirano, S. Browse this author
Matsuno, Y. Browse this author
Keywords: EMT
extrahepatic cholangiocarcinoma
immunohistochemistry
tissue microarray
prognosis
survival
cadherin switch
Issue Date: 23-Sep-2014
Publisher: Nature Publishing Group
Journal Title: British Journal of Cancer
Volume: 111
Issue: 7
Start Page: 1363
End Page: 1372
Publisher DOI: 10.1038/bjc.2014.415
Abstract: Background: Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express different isoforms of the cadherin transmembrane protein and usually refers to a switch from the expression of E-cadherin to N-cadherin, is one aspect of EMT and can have a profound effect on tumour invasion/metastasis. The aim of this study was to investigate the clinicopathological significance of EMT-related proteins and cadherin switch in extrahepatic cholangiocarcinoma (EHCC). Methods: We investigated the association between altered expression of 12 EMT-related proteins and clinical outcomes in patients with EHCC (n = 117) using immunohistochemistry on tissue microarrays. Results: Univariate and multivariate analyses revealed that, in addition to N classification (P = 0.0420), the expression of E-cadherin (P = 0.0208), N-cadherin (P = 0.0038) and S100A4 (P = 0.0157) was each an independent and a significant prognostic factor. We also demonstrated that cadherin switch was independently associated with poor prognosis (P = 0.0143) in patients with EHCC. Conclusions: These results may provide novel information for selection of patients with EHCC who require adjuvant therapy and strict surveillance.
Description: Supplementary Information accompanies this paper on British Journal of Cancer website.
Description URI: http://www.nature.com/bjc/journal/v111/n7/suppinfo/bjc2014415s1.html
Rights: http://creativecommons.org/licenses/by-nc-sa/3.0/
Type: article
URI: http://hdl.handle.net/2115/59851
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三橋 智子

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