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Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray
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| Title: | Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray |
| Authors: | Nitta, T. Browse this author | | Mitsuhashi, Tomoko Browse this author →KAKEN DB | | Hatanaka, Y. Browse this author | | Miyamoto, M. Browse this author | | Oba, K. Browse this author | | Tsuchikawa, T. Browse this author | | Suzuki, Y. Browse this author | | Hatanaka, K. C. Browse this author | | Hirano, S. Browse this author | | Matsuno, Y. Browse this author |
| Keywords: | EMT | | extrahepatic cholangiocarcinoma | | immunohistochemistry | | tissue microarray | | prognosis | | survival | | cadherin switch |
| Issue Date: | 23-Sep-2014 |
| Publisher: | Nature Publishing Group |
| Journal Title: | British Journal of Cancer |
| Volume: | 111 |
| Issue: | 7 |
| Start Page: | 1363 |
| End Page: | 1372 |
| Publisher DOI: | 10.1038/bjc.2014.415 |
| Abstract: | Background: Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express different isoforms of the cadherin transmembrane protein and usually refers to a switch from the expression of E-cadherin to N-cadherin, is one aspect of EMT and can have a profound effect on tumour invasion/metastasis. The aim of this study was to investigate the clinicopathological significance of EMT-related proteins and cadherin switch in extrahepatic cholangiocarcinoma (EHCC). Methods: We investigated the association between altered expression of 12 EMT-related proteins and clinical outcomes in patients with EHCC (n = 117) using immunohistochemistry on tissue microarrays. Results: Univariate and multivariate analyses revealed that, in addition to N classification (P = 0.0420), the expression of E-cadherin (P = 0.0208), N-cadherin (P = 0.0038) and S100A4 (P = 0.0157) was each an independent and a significant prognostic factor. We also demonstrated that cadherin switch was independently associated with poor prognosis (P = 0.0143) in patients with EHCC. Conclusions: These results may provide novel information for selection of patients with EHCC who require adjuvant therapy and strict surveillance. |
| Description: | Supplementary Information accompanies this paper on British Journal of Cancer website. |
| Description URI: | http://www.nature.com/bjc/journal/v111/n7/suppinfo/bjc2014415s1.html |
| Rights: | http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/59851 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三橋 智子
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