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The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia

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Title: The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia
Authors: Simulundu, Edgar Browse this author
Nao, Naganori Browse this author
Yabe, John Browse this author
Muto, Nilton A. Browse this author
Sithebe, Thami Browse this author
Sawa, Hirofumi Browse this author →KAKEN DB
Manzoor, Rashid Browse this author
Kajihara, Masahiro Browse this author
Muramatsu, Mieko Browse this author
Ishii, Akihiro Browse this author →KAKEN DB
Ogawa, Hirohito Browse this author
Mweene, Aaron S. Browse this author
Takada, Ayato Browse this author →KAKEN DB
Issue Date: Oct-2014
Publisher: Springer
Journal Title: Archives of Virology
Volume: 159
Issue: 10
Start Page: 2633
End Page: 2640
Publisher DOI: 10.1007/s00705-014-2124-1
PMID: 24862188
Abstract: Whilst remarkable progress in elucidating the mechanisms governing interspecies transmission and pathogenicity of highly pathogenic avian influenza viruses (AIVs) has been made, similar studies focusing on low-pathogenic AIVs isolated from the wild waterfowl reservoir are limited. We previously reported that two AIV strains (subtypes H6N2 and H3N8) isolated from wild waterfowl in Zambia harbored some amino acid residues preferentially associated with human influenza virus proteins (so-called human signatures) and replicated better in the lungs of infected mice and caused more morbidity than a strain lacking such residues. To further substantiate these observations, we infected chickens and mice intranasally with AIV strains of various subtypes (H3N6, H3N8, H4N6, H6N2, H9N1 and H11N9) isolated from wild waterfowl in Zambia. Although some strains induced seroconversion, all of the tested strains replicated poorly and were nonpathogenic for chickens. In contrast, most of the strains having human signatures replicated well in the lungs of mice, and one of these strains caused severe illness in mice and induced lung injury that was characterized by a severe accumulation of polymorphonuclear leukocytes. These results suggest that some strains tested in this study may have the potential to infect mammalian hosts directly without adaptation, which might possibly be associated with the possession of human signature residues. Close monitoring and evaluation of host-associated signatures may help to elucidate the prevalence and emergence of AIVs with potential for causing zoonotic infections.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田 礼人

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