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Bone Augmentation by Implantation of an FGF2-loaded Collagen Gel-sponge Composite Scaffold

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Title: Bone Augmentation by Implantation of an FGF2-loaded Collagen Gel-sponge Composite Scaffold
Authors: KOBAYASHI, Naoko1 Browse this author
MIYAJI, Hirofumi2 Browse this author →KAKEN DB
SUGAYA, Tsutomu3 Browse this author →KAKEN DB
KAWANAMI, Masamitsu4 Browse this author →KAKEN DB
Authors(alt): KOBAYASHI, Naoko1
MIYAJI, Hirofumi2
SUGAYA, Tsutomu3
KAWANAMI, Masamitsu4
Keywords: FGF2
collagen gel-sponge
composite scaffold
bone augmentation
Issue Date: 30-Dec-2010
Publisher: Japanese Association of Regenerative Dentistry
Journal Title: Journal of Oral Tissue Engineering
Volume: 8
Issue: 2
Start Page: 91
End Page: 101
Publisher DOI: 10.11223/jarde.8.91
Abstract: Fibroblast growth factor-2 (FGF2) plays a critical role in osteoblastic cell proliferation. Collagen gel-sponge composite is an effective scaffold for tissue engineering. The purpose of this study was to evaluate whether addition of FGF2 to collagen gel-sponge composite promotes bone augmentation in rats.The rats were assigned to groups designated F0, F3 and F15, and received implantation of collagen gel-sponge composite containing 0, 3 and 15 µg FGF2, respectively, into a cranial bone defect. Specimens were prepared 1, 2 and 5 weeks after surgery for histologic and histomorphometric analysis.Newly formed bone area in groups F3 and F15 was significantly greater than that in group F0 at all stages. These results suggest that FGF2-loaded collagen gel-sponge composite scaffold stimulates bone augmentation and might provide a more effective bone engineering approach.
Rights: 日本再生歯科医学会(利用は著作権の範囲内に限られます)
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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