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Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet

2010 Inoue J Oral Tissue Engin.pdf868.47 kBPDF見る/開く

タイトル: Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet
著者: INOUE, Kana 著作を一覧する
MIYAJI, Hirofumi 著作を一覧する
SUGAYA, Tsutomu 著作を一覧する
KAWANAMI, Masamitsu 著作を一覧する
キーワード: bone tissue engineering
bone marrow stromal cell
cell sheet
collagen sponge scaffold
発行日: 2010年 9月30日
出版者: Japanese Association of Regenerative Dentistry
誌名: Journal of Oral Tissue Engineering
巻: 8
号: 1
開始ページ: 19
終了ページ: 29
出版社 DOI: 10.11223/jarde.8.19
抄録: We combined the use of bone morphogenetic protein-2(BMP-2)-loaded collagen scaffold and cultured bone marrow stromal cell (BMSC) sheet in order for developing new bone tissue engineering.Rat BMSC sheets were generated in the presence of dexamethasone, β-glycerophosphate and ascorbic acid. Four types of the grafts were implanted in the intermuscular region of rat femurs: control group, collagen sponge; cell group, BMSC sheet in collagen sponge; BMP group, BMP-2-loaded collagen sponge; and BMP-cell group, BMSC sheet in BMP-2-loaded collagen sponge. Four weeks after surgery, histological and histomorphometric analysis were performed.The BMP-cell group demonstrated abundant new bone formation compared to all the other groups (p<0.05) and marked resorption of the implanted collagen when compared to the control and cell groups (p<0.05).The combination of BMP-2-loaded collagen sponge and BMSC sheet appeared to successfully promote an osteoinduction.
Rights: 日本再生歯科医学会(利用は著作権の範囲内に限られます)
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 宮治 裕史


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