Model for calcium-mediated reduction of structural fluctuations in epidermis


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PhysRevE.92.022709.pdf

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/59887

Title:	Model for calcium-mediated reduction of structural fluctuations in epidermis
Authors:	Kobayashi, Yasuaki Browse this author
	Kitahata, Hiroyuki Browse this author →KAKEN DB
	Nagayama, Masaharu Browse this author →KAKEN DB
Issue Date:	13-Aug-2015
Publisher:	American Physical Society
Journal Title:	Physical review E
Volume:	92
Issue:	2
Start Page:	022709-1
End Page:	022709-7
Publisher DOI:	10.1103/PhysRevE.92.022709
PMID:	26382434
Abstract:	We propose a reaction-advection-diffusion model of epidermis consisting of two variables, the degree of differentiation and the calcium ion concentration, where calcium ions enhance differentiation. By analytically and numerically investigating this system, we show that a calcium localization layer formed beneath the stratum corneum helps reduce spatiotemporal fluctuations of the structure of the stratum corneum. In particular, spatially or temporally small-scale fluctuations in the lower structure are suppressed and do not affect the upper structure, due to acceleration of differentiation by calcium ions. Analytical expressions for the reduction rate of fluctuation amplitudes are shown.
Rights:	©2015 American Physical Society
Type:	article
URI:	http://hdl.handle.net/2115/59887
Appears in Collections:	電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林康明

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