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Gastric emptying is involved in Lactobacillus colonisation in mouse stomach
| Title: | Gastric emptying is involved in Lactobacillus colonisation in mouse stomach |
| Authors: | Sahasakul, Yuraporn Browse this author | | Takemura, Naoki Browse this author | | Sonoyama, Kei Browse this author →KAKEN DB |
| Keywords: | Gastric emptying | | Lactobacilli | | Stomach | | Mice |
| Issue Date: | 14-Aug-2014 |
| Publisher: | Cambridge University Press |
| Journal Title: | British Journal of Nutrition |
| Volume: | 112 |
| Issue: | 3 |
| Start Page: | 408 |
| End Page: | 415 |
| Publisher DOI: | 10.1017/S0007114514000968 |
| PMID: | 24933648 |
| Abstract: | Lactobacilli are indigenous microbes of the stomach of rodents, with much lower numbers being present in mice fed a purified diet than in those fed a non-purified diet. We postulated that gastric emptying (GE) is responsible for the different colonisation levels of lactobacilli and tested this hypothesis in the present study. BALB/cCr Slc mice were fed either a non-purified diet or a purified diet for 2 weeks. The number of gastric tissue-associated lactobacilli was lower in mice fed the purified diet than in those fed the non-purified diet. GE, estimated by measuring the food recovered from the stomach, was higher in mice fed the purified diet than in those fed the non-purified diet and correlated negatively with the number of lactobacilli. Mice fed the non-purified diet exhibited lower GE rates even when lactobacilli were eliminated by ampicillin administration through the drinking-water, suggesting that GE is the cause but not the consequence of different Lactobacillus colonisation levels. The plasma concentrations of acylated ghrelin, a gastric hormone that promotes GE, were higher in mice fed the purified diet than in those fed the non-purified diet. There was a negative correlation between GE and the number of lactobacilli in mice fed the non-purified diet, the purified diet, and the purified diet supplemented with sugarbeet fibre (200 g/kg diet) or carboxymethyl cellulose (40 g/kg diet). We propose that a higher GE rate contributes, at least in part, to lower gastric colonisation levels of lactobacilli in mice fed a purified diet. |
| Rights: | © Cambridge University Press |
| Type: | article |
| URI: | http://hdl.handle.net/2115/60047 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 園山 慶
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