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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use
| Title: | Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use |
| Authors: | Arsiningtyas, Ines Septi Browse this author | | Gunawan-Puteri, Maria D. P. T. Browse this author | | Kato, Eisuke Browse this author →KAKEN DB | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Indonesian herb | | intestinal maltase inhibitor | | diabetes mellitus | | Pluchea indica | | caffeoylquinic acid derivatives |
| Issue Date: | 15-Oct-2015 |
| Publisher: | Taylor & Francis |
| Journal Title: | Natural Product Research |
| Volume: | 28 |
| Issue: | 17 |
| Start Page: | 1350 |
| End Page: | 1353 |
| Publisher DOI: | 10.1080/14786419.2014.904306 |
| PMID: | 24697406 |
| Abstract: | A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using a-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidated by mass spectrometry and NMR analysis and completed by comparison with reference data. 3,5-Di-O-caffeoylquinic acid (1), 4,5-di-O-caffeoylquinic acid methyl ester (2), 3,4,5-tri-O-caffeoylquinic acid methyl ester (3), 3,4,5-tri-O-caffeoylquinic acid (4) and 1,3,4,5-tetra-O-caffeoylquinic acid (5) were isolated. Comparison of the activities of each isolate suggested that both methyl esterification of quinic acid and the number of caffeate groups in the molecule were important for the inhibitory activity. This study provides basic information for further examination of the suitability of P. indica as a functional food and medicinal supplement for the treatment and prevention of diabetes. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/DOI:10.1080/14786419.2014.904306. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/60048 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 川端 潤
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