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Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/60048

Title: Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use
Authors: Arsiningtyas, Ines Septi Browse this author
Gunawan-Puteri, Maria D. P. T. Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Indonesian herb
intestinal maltase inhibitor
diabetes mellitus
Pluchea indica
caffeoylquinic acid derivatives
Issue Date: 15-Oct-2015
Publisher: Taylor & Francis
Journal Title: Natural Product Research
Volume: 28
Issue: 17
Start Page: 1350
End Page: 1353
Publisher DOI: 10.1080/14786419.2014.904306
PMID: 24697406
Abstract: A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using a-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidated by mass spectrometry and NMR analysis and completed by comparison with reference data. 3,5-Di-O-caffeoylquinic acid (1), 4,5-di-O-caffeoylquinic acid methyl ester (2), 3,4,5-tri-O-caffeoylquinic acid methyl ester (3), 3,4,5-tri-O-caffeoylquinic acid (4) and 1,3,4,5-tetra-O-caffeoylquinic acid (5) were isolated. Comparison of the activities of each isolate suggested that both methyl esterification of quinic acid and the number of caffeate groups in the molecule were important for the inhibitory activity. This study provides basic information for further examination of the suitability of P. indica as a functional food and medicinal supplement for the treatment and prevention of diabetes.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/DOI:10.1080/14786419.2014.904306.
Type: article (author version)
URI: http://hdl.handle.net/2115/60048
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川端 潤

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