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Visualization of the entire differentiation process of murine M cells : suppression of their maturation in cecal patches

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Title: Visualization of the entire differentiation process of murine M cells : suppression of their maturation in cecal patches
Authors: Kimura, Shunsuke Browse this author →KAKEN DB
Yamakami-Kimura, Megumi Browse this author
Obata, Yuuki Browse this author
Hase, Koji Browse this author
Kitamura, Hiroshi Browse this author →KAKEN DB
Ohno, Hiroshi Browse this author →KAKEN DB
Iwanaga, Toshihiko Browse this author →KAKEN DB
Issue Date: May-2015
Publisher: Nature Publishing Group
Journal Title: Mucosal immunology
Volume: 8
Issue: 3
Start Page: 650
End Page: 660
Publisher DOI: 10.1038/mi.2014.99
PMID: 25336168
Abstract: The microfold (M) cell residing in the follicle-associated epithelium is a specialized epithelial cell that initiates mucosal immune responses by sampling lumina! antigens. The differentiation process of M cells remains unclear due to limitations of analytical methods. Here we found that M cells were classified into two functionally different subtypes based on the expression of Glycoprotein 2 (GP2) by newly developed image cytometric analysis. GP2-high M cells actively took up luminal microbeads, whereas GP2-negative or low cells scarcely ingested them, even though both subsets equally expressed the other M-cell signature genes, suggesting that GP2-high M cells represent functionally mature M cells. Further, the GP2-high mature M cells were abundant in Peyer's patch but sparse in the cecal patch: this was most likely due to a decrease in the nuclear translocation of RelB, a downstream transcription factor for the receptor activator of nuclear factor-kappa B signaling. Given that murine cecum contains a protrusion of beneficial commensals, the restriction of M-cell activity might contribute to preventing the onset of any excessive immune response to the commensals through decelerating the M-cell-dependent uptake of microorganisms.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 俊介

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