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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Effects of supplemental oxygen on urinary 8-hydroxy-2’-deoxyguanosine levels in extremely low birth weight infants
| Title: | Effects of supplemental oxygen on urinary 8-hydroxy-2’-deoxyguanosine levels in extremely low birth weight infants |
| Authors: | Kato, Eiji Browse this author | | Ibara, Satoshi Browse this author | | Kumazawa, Kazumasa Browse this author | | Maruyama, Yuko Browse this author | | Tokuhisa, Takuya Browse this author | | Matsui, Takako Browse this author | | Shimono, Ryuichi Browse this author | | Maede, Yoshinobu Browse this author | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | biomarker | | oxidative stress | | oxygen supplementation | | preterm infants | | reactive oxygen species |
| Issue Date: | Nov-2014 |
| Publisher: | Informa Healthcare |
| Journal Title: | Free Radical Research |
| Volume: | 48 |
| Issue: | 11 |
| Start Page: | 1285 |
| End Page: | 1290 |
| Publisher DOI: | 10.3109/10715762.2014.951841 |
| Abstract: | As the effects of supplementary oxygen on urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG) are poorly understood, urinary 8-OHdG levels (ng/mg creatinine) were determined longitudinally on the postnatal day (PND) 1, 3, and 30 in 16 neonates with birth weight < 1000 g. No supplementary oxygen was required in 9 neonates during the first 24 h of life. Urinary 8-OHdG level on PND 1 was inversely correlated with birth weight in these 9 neonates (P = 0.0323) and was higher in four with birth weight < 750 g than five with birth weight > 750 g (41.0 +/- 6.9 vs. 5.6 +/- 2.7, respectively, P = 0.0200). Median urinary 8-OHdG on PND 1 of these 9 neonates was significantly lower than that of 7 neonates with oxygen (9.3 vs. 60.2, respectively), although there were no significant differences in clinical background, such as birth weight, between the two groups. Five of the 9 did not require supplemental oxygen at all during the first 30 days of life. Median urinary 8-OHdG levels were consistently significantly lower in the 5 neonates than in 11 neonates with oxygen transiently or persistently (9.3 vs. 54.6, 19.1 vs. 61.4, and 28.3 vs. 145 on PND 1, 3, and 30, respectively), although there were no differences in clinical background, such as birth weight, between the two groups. Urinary 8-OHdG on PND 30 was significantly positively correlated with supplemental oxygen dose on PND 30 (P < 0.0001), but not with birth weight in the 16 neonates. These results suggest that higher supplemental oxygen tension caused higher urinary 8-OHdG in this population. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/60251 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水上 尚典
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