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Cell Chirality Induces Collective Cell Migration in Epithelial Sheets
| Title: | Cell Chirality Induces Collective Cell Migration in Epithelial Sheets |
| Authors: | Sato, Katsuhiko Browse this author →KAKEN DB | | Hiraiwa, Tetsuya Browse this author | | Shibata, Tatsuo Browse this author |
| Issue Date: | 30-Oct-2015 |
| Publisher: | American Physical Society |
| Journal Title: | Physical review letters |
| Volume: | 115 |
| Issue: | 18 |
| Start Page: | 188102-1 |
| End Page: | 188102-5 |
| Publisher DOI: | 10.1103/PhysRevLett.115.188102 |
| PMID: | 26565500 |
| Abstract: | During early development, epithelial cells form a monolayer sheet and migrate in a uniform direction. Here, we address how this collective migration can occur without breaking the cell-to-cell attachments. Repeated contraction and expansion of the cell-to-cell interfaces enables the cells to rearrange their positions autonomously within the sheet. We show that when the interface tension is strengthened in a direction that is tilted from the body axis, cell rearrangements occur in such a way that unidirectional movement is induced. We use a vertex model to demonstrate that such anisotropic tension can generate the unidirectional motion of cell sheets. Our results suggest that cell chirality facilitates collective cell migration during tissue morphogenesis. |
| Rights: | ©2015 American Physical Society |
| Type: | article |
| URI: | http://hdl.handle.net/2115/60271 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 勝彦
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