HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Research Institute for Electronic Science >
Peer-reviewed Journal Articles, etc >

Cell Chirality Induces Collective Cell Migration in Epithelial Sheets

Files in This Item:
PhysRevLett.115.188102.pdf322.48 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Cell Chirality Induces Collective Cell Migration in Epithelial Sheets
Authors: Sato, Katsuhiko Browse this author →KAKEN DB
Hiraiwa, Tetsuya Browse this author
Shibata, Tatsuo Browse this author
Issue Date: 30-Oct-2015
Publisher: American Physical Society
Journal Title: Physical review letters
Volume: 115
Issue: 18
Start Page: 188102-1
End Page: 188102-5
Publisher DOI: 10.1103/PhysRevLett.115.188102
PMID: 26565500
Abstract: During early development, epithelial cells form a monolayer sheet and migrate in a uniform direction. Here, we address how this collective migration can occur without breaking the cell-to-cell attachments. Repeated contraction and expansion of the cell-to-cell interfaces enables the cells to rearrange their positions autonomously within the sheet. We show that when the interface tension is strengthened in a direction that is tilted from the body axis, cell rearrangements occur in such a way that unidirectional movement is induced. We use a vertex model to demonstrate that such anisotropic tension can generate the unidirectional motion of cell sheets. Our results suggest that cell chirality facilitates collective cell migration during tissue morphogenesis.
Rights: ©2015 American Physical Society
Type: article
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 勝彦

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University