Title: | Usefulness of C-11-methionine-positron emission tomography for the diagnosis of progressive multifocal leukoencephalopathy |
Authors: | Shirai, Shinichi Browse this author |
Yabe, Ichiro Browse this author →KAKEN DB |
Kano, Takahiro Browse this author |
Shimizu, Yuka Browse this author |
Sasamori, Toru Browse this author |
Sato, Kazunori Browse this author |
Hirotani, Makoto Browse this author →KAKEN DB |
Nonaka, Takayuki Browse this author |
Takahashi, Ikuko Browse this author |
Matsushima, Masaaki Browse this author |
Minami, Naoya Browse this author |
Nakamichi, Kazuo Browse this author →KAKEN DB |
Saijo, Masayuki Browse this author |
Hatanaka, Kanako C. Browse this author |
Shiga, Tohru Browse this author →KAKEN DB |
Tanaka, Shinya Browse this author →KAKEN DB |
Sasaki, Hidenao Browse this author →KAKEN DB |
Keywords: | Progressive multifocal leukoencephalopathy |
C-11-methionine-positron emission tomography |
F-18-fluorodeoxyglucose-positron emission tomography |
Mefloquine |
Issue Date: | Dec-2014 |
Publisher: | Springer |
Journal Title: | Journal of neurology |
Volume: | 261 |
Issue: | 12 |
Start Page: | 2314 |
End Page: | 2318 |
Publisher DOI: | 10.1007/s00415-014-7500-y |
PMID: | 25223960 |
Abstract: | Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease of the brain caused by the JC virus that occurs mainly in immunocompromised patients. The prognosis is very poor. As the lesion looks like non- specific leukoencephalopathy, making a diagnosis at the early stage is very difficult. We report three PML cases in which there was a mismatch between C-11-methionine-positron emission tomography (MET-PET) uptake and F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) uptake. All three cases demonstrated the hyper-uptake of MET around the white matter lesions and hypo-uptake of FDG inside the lesions. We speculate that the infection had ended inside the white matter lesions of these patients, while JC virus infection was ongoing around the lesions, resulting in the increase of methionine metabolism, and the glucose metabolism was reduced or intermediate because inflammatory cells infiltrate PML lesions rarely. Two patients who were diagnosed and treated with mefloquine while the JC virus was at a low level in the cerebrospinal fluid are still alive. We suggest the usefulness of MET-PET for the early diagnosis of PML and early treatment with mefloquine. |
Rights: | The final publication is available at link.springer.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/60294 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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