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Application of radiosurgical techniques to produce a primate model of brain lesions

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Title: Application of radiosurgical techniques to produce a primate model of brain lesions
Authors: Kunimatsu, Jun Browse this author →KAKEN DB
Miyamoto, Naoki Browse this author →KAKEN DB
Ishikawa, Masayori Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: radiation
LINAC
frontal eye field
saccade
smooth pursuit
monkey
Issue Date: 24-Apr-2015
Publisher: Frontiers Media
Journal Title: Frontiers in systems neuroscience
Volume: 9
Start Page: 67
Publisher DOI: 10.3389/fnsys.2015.00067
Abstract: Behavioral analysis of subjects with discrete brain lesions provides important information about the mechanisms of various brain functions. However, it is generally difficult to experimentally produce discrete lesions in deep brain structures. Here we show that a radiosurgical technique, which is used as an alternative treatment for brain tumors and vascular malformations, is applicable to create non-invasive lesions in experimental animals for the research in systems neuroscience. We delivered highly focused radiation (130-150 Gy at ISO center) to the frontal eye field (FEF) of macaque monkeys using a clinical linear accelerator (LINAC). The effects of irradiation were assessed by analyzing oculomotor performance along with magnetic resonance (MR) images before and up to 8 months following irradiation. In parallel with tissue edema indicated by MR images, deficits in saccadic and smooth pursuit eye movements were observed during several days following irradiation. Although initial signs of oculomotor deficits disappeared within a month, damage to the tissue and impaired eye movements gradually developed during the course of the subsequent 6 months. Postmortem histological examinations showed necrosis and hemorrhages within a large area of the white matter and, to a lesser extent, in the adjacent gray matter, which was centered at the irradiated target. These results indicated that the LINAC system was useful for making brain lesions in experimental animals, while the suitable radiation parameters to generate more focused lesions need to be further explored. We propose the use of a radiosurgical technique for establishing animal models of brain lesions, and discuss the possible uses of this technique for functional neurosurgical treatments in humans.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/60417
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 國松 淳

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