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Emerging Therapeutic Biomarkers in Endometrial Cancer

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/60534

Title: Emerging Therapeutic Biomarkers in Endometrial Cancer
Authors: Dong, Peixin Browse this author
Kaneuchi, Masanori Browse this author
Konno, Yosuke Browse this author
Watari, Hidemichi Browse this author →KAKEN DB
Sudo, Satoko Browse this author →KAKEN DB
Sakuragi, Noriaki Browse this author →KAKEN DB
Issue Date: 2013
Publisher: Hindawi Publishing Corporation
Journal Title: BioMed Research International
Volume: 2013
Start Page: 1
End Page: 11
Publisher DOI: 10.1155/2013/130362
Abstract: Although clinical trials of molecular therapies targeting critical biomarkers (mTOR, epidermal growth factor receptor/epidermal growth factor receptor 2, and vascular endothelial growth factor) in endometrial cancer show modest effects, there are still challenges that might remain regarding primary/acquired drug resistance and unexpected side effects on normal tissues. New studies that aim to target both genetic and epigenetic alterations (noncoding microRNA) underlying malignant properties of tumor cells and to specifically attack tumor cells using cell surface markers overexpressed in tumor tissue are emerging. More importantly, strategies that disrupt the cancer stem cell/epithelial-mesenchymal transition-dependent signals and reactivate antitumor immune responses would bring new hope for complete elimination of all cell compartments in endometrial cancer. We briefly review the current status of molecular therapies tested in clinical trials and mainly discuss the potential therapeutic candidates that are possibly used to develop more effective and specific therapies against endometrial cancer progression and metastasis.
Rights: Copyright © 2013 Peixin Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/60534
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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