HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
医学研究院・医学院  >
雑誌発表論文等  >

Prognostic significance of miR-194 in endometrial cancer


6.pdf261.4 kBPDF見る/開く

タイトル: Prognostic significance of miR-194 in endometrial cancer
著者: Zhai, Haiyan 著作を一覧する
Karaayvaz, Mihriban 著作を一覧する
Dong, Peixin 著作を一覧する
Sakuragi, Noriaki 著作を一覧する
Ju, Jingfang 著作を一覧する
キーワード: MiR-194
Endometrial cancer
発行日: 2013年 2月18日
出版者: BioMed Central
誌名: Biomarker Research
巻: 1
号: 1
開始ページ: 12
出版社 DOI: 10.1186/2050-7771-1-12
抄録: Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 董 培新


本サイトに関するご意見・お問い合わせは repo at へお願いします。 - 北海道大学