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Prognostic significance of miR-194 in endometrial cancer

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Title: Prognostic significance of miR-194 in endometrial cancer
Authors: Zhai, Haiyan Browse this author
Karaayvaz, Mihriban Browse this author
Dong, Peixin Browse this author
Sakuragi, Noriaki Browse this author →KAKEN DB
Ju, Jingfang Browse this author
Keywords: MiR-194
Endometrial cancer
Issue Date: 18-Feb-2013
Publisher: BioMed Central
Journal Title: Biomarker Research
Volume: 1
Issue: 1
Start Page: 12
Publisher DOI: 10.1186/2050-7771-1-12
Abstract: Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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