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Improvement of cerebral hypometabolism after resection of radiation-induced necrotic lesion in a patient with cerebral arteriovenous malformation

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Title: Improvement of cerebral hypometabolism after resection of radiation-induced necrotic lesion in a patient with cerebral arteriovenous malformation
Authors: Harada, Yae Browse this author
Hirata, Kenji Browse this author →KAKEN DB
Nakayama, Naoki Browse this author →KAKEN DB
Yamaguchi, Shigeru Browse this author
Yoshida, Michiharu Browse this author
Onodera, Shunsuke Browse this author
Manabe, Osamu Browse this author →KAKEN DB
Shiga, Tohru Browse this author →KAKEN DB
Terae, Satoshi Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Intracranial arteriovenous malformation
stereotactic radiosurgery
radiation-induced necrosis
brain edema
F-18 fluorodeoxyglucose
positron emission tomography
Issue Date: 29-Jun-2015
Publisher: SAGE Publications
Journal Title: Acta radiologica open
Volume: 4
Issue: 6
Start Page: 2058460115584112
Publisher DOI: 10.1177/2058460115584112
Abstract: A 55-year-old woman underwent radiosurgery for a left cerebral hemisphere arteriovenous malformation (AVM) and developed radiation-induced necrosis causing a massive edema in the surrounding brain tissues. Despite various therapies, the edema expanded to the ipsilateral hemisphere and induced neurological symptoms. The radiation-induced necrotic lesion was surgically removed 4 years after radiosurgery. While the preoperative FDG PET revealed severe hypometabolism in the left cerebrum, the necrotomy significantly ameliorated the brain edema, glucose metabolism (postoperative FDG PET), and symptoms. This case indicates that radiation necrosis-induced neurological deficits may be associated with brain edema and hypometabolism, which could be reversed by appropriate necrotomy.
Rights: http://creativecommons.org/licenses/by-nc/3.0/
Type: article
URI: http://hdl.handle.net/2115/60585
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

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