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Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/60630

Title: Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses
Authors: Sasaki, Michihito Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Ueno, Keisuke Browse this author →KAKEN DB
Ishii, Akihiro Browse this author →KAKEN DB
Moonga, Ladslav Browse this author
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Ito, Kimihito Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: Feb-2015
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 96
Issue: 2
Start Page: 440
End Page: 452
Publisher DOI: 10.1099/vir.0.071209-0
PMID: 25381053
Abstract: Shrews are small insectivorous mammals that are distributed worldwide. Similar to rodents, shrews live on the ground and are commonly found near human residences. In this study, we investigated the enteric virome of wild shrews in the genus Crocidura using a sequence-independent viral metagenomics approach. A large portion of the shrew enteric virome was composed of insect viruses, whilst novel viruses including cyclovirus, picornavirus and picorna-like virus were also identified. Several cycloviruses, including variants of human cycloviruses detected in cerebrospinal fluid and stools, were detected in wild shrews at a high prevalence rate. The identified picornavirus was distantly related to human parechovirus, inferring the presence of a new genus in this family. The identified picorna-like viruses were characterized as different species of calhevirus 1, which was discovered previously in human stools. Complete or nearly complete genome sequences of these novel viruses were determined in this study and then were subjected to further genetic characterization. Our study provides an initial view of the diversity and distinctiveness of the shrew enteric virome and highlights unique novel viruses related to human stool-associated viruses.
Type: article (author version)
URI: http://hdl.handle.net/2115/60630
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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