|
Hokkaido University Collection of Scholarly and Academic Papers >
International Institute for Zoonosis Control >
Peer-reviewed Journal Articles, etc >
Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses
| Title: | Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses |
| Authors: | Sasaki, Michihito Browse this author →KAKEN DB | | Orba, Yasuko Browse this author →KAKEN DB | | Ueno, Keisuke Browse this author →KAKEN DB | | Ishii, Akihiro Browse this author →KAKEN DB | | Moonga, Ladslav Browse this author | | Hang'ombe, Bernard M. Browse this author | | Mweene, Aaron S. Browse this author | | Ito, Kimihito Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB |
| Issue Date: | Feb-2015 |
| Publisher: | Society for General Microbiology |
| Journal Title: | Journal of General Virology |
| Volume: | 96 |
| Issue: | 2 |
| Start Page: | 440 |
| End Page: | 452 |
| Publisher DOI: | 10.1099/vir.0.071209-0 |
| PMID: | 25381053 |
| Abstract: | Shrews are small insectivorous mammals that are distributed worldwide. Similar to rodents, shrews live on the ground and are commonly found near human residences. In this study, we investigated the enteric virome of wild shrews in the genus Crocidura using a sequence-independent viral metagenomics approach. A large portion of the shrew enteric virome was composed of insect viruses, whilst novel viruses including cyclovirus, picornavirus and picorna-like virus were also identified. Several cycloviruses, including variants of human cycloviruses detected in cerebrospinal fluid and stools, were detected in wild shrews at a high prevalence rate. The identified picornavirus was distantly related to human parechovirus, inferring the presence of a new genus in this family. The identified picorna-like viruses were characterized as different species of calhevirus 1, which was discovered previously in human stools. Complete or nearly complete genome sequences of these novel viruses were determined in this study and then were subjected to further genetic characterization. Our study provides an initial view of the diversity and distinctiveness of the shrew enteric virome and highlights unique novel viruses related to human stool-associated viruses. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/60630 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 佐々木 道仁
|
