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Orthopoxvirus infection among wildlife in Zambia

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/60631

Title: Orthopoxvirus infection among wildlife in Zambia
Authors: Orba, Yasuko Browse this author →KAKEN DB
Sasaki, Michihito Browse this author →KAKEN DB
Yamaguchi, Hiroki Browse this author
Ishii, Akihiro Browse this author →KAKEN DB
Thomas, Yuka Browse this author
Ogawa, Hirohito Browse this author
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Morikawa, Shigeru Browse this author →KAKEN DB
Saijo, Masayuki Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: Feb-2015
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 96
Issue: 2
Start Page: 390
End Page: 394
Publisher DOI: 10.1099/vir.0.070219-0
PMID: 25319753
Abstract: Human monkeypox is a viral zoonosis caused by monkeypox virus, an orthopoxvirus (OPXV). The majority of human monkeypox cases have been reported in moist forested regions in West and Central Africa, particularly in the Democratic Republic of the Congo (DRC). In this study we investigated zoonotic OPXV infection among wild animals in Zambia, which shares a border with DRC, to assess the geographical distribution of OPXV. We screened for OPXV antibodies in sera from non-human primates (NHPs), rodents and shrews by ELISA, and performed real-time PCR to detect OPXV DNA in spleen samples. Serological analysis indicated that 38 of 259 (14.7 %) rodents, 14 of 42 (33.3%) shrews and 4 of 188 (2.1 %) NHPs had antibodies against OPXV. The OPXV DNA could not be detected in spleens from any animals tested. Our results indicated that wild animals living in rural human habitation areas of Zambia have been infected with OPXV.
Type: article (author version)
URI: http://hdl.handle.net/2115/60631
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大場 靖子

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