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Glucocorticoids Reset the Nasal Circadian Clock in Mice

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Title: Glucocorticoids Reset the Nasal Circadian Clock in Mice
Authors: Honma, Aya Browse this author
Yamada, Yoshiko Browse this author
Nakamaru, Yuji Browse this author
Fukuda, Satoshi Browse this author →KAKEN DB
Honma, Ken-ichi Browse this author →KAKEN DB
Honma, Sato Browse this author →KAKEN DB
Issue Date: Nov-2015
Publisher: Endocrine Society
Journal Title: Endocrinology
Volume: 156
Issue: 11
Start Page: 4302
End Page: 4311
Publisher DOI: 10.1210/en.2015-1490
PMID: 26360505
Abstract: The symptoms of allergic rhinitis show marked day-night changes that are likely to be under the control of the circadian clock, but the mechanism of this control is poorly understood. Because most peripheral tissues have endogenous circadian clocks, we examined the circadian rhythm of the clock gene product PERIOD2 (PER2) in the nasal mucosa of male mice using a luciferase reporter and demonstrated for the first time the phase-dependent effects of dexamethasone (DEX) on nasal PER2 rhythm in vivo and ex vivo. The phase shifts in PER2 rhythm caused by DEX were observed around the peak phase of serum glucocorticoids, suggesting that the circadian rhythm of endogenous glucocorticoids regulates the peripheral clock of the mouse nasal mucosa. From the viewpoint of circadian physiology, the best time to administer intranasal steroid treatment for allergic rhinitis would be when no phase shift is caused by DEX: in the early evening in diurnal humans.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 さと

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