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Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes

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Title: Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes
Authors: Ishihara, Rino Browse this author
Mizuno, Yuki Browse this author
Miwa, Akiho Browse this author
Hamada, Akihiro Browse this author
Tsuruta, Takeshi Browse this author
Wabitsch, Martin Browse this author
Sonoyama, Kei Browse this author →KAKEN DB
Keywords: Leptin
Issue Date: 7-Mar-2015
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 458
Issue: 2
Start Page: 362
End Page: 368
Publisher DOI: 10.1016/j.bbrc.2015.01.118
PMID: 25656573
Abstract: Although leptin and adiponectin are the predominant adipokines, how their circulating levels are regulated is incompletely understood. The present study tested whether intestinal epithelial cells influence the expression and secretion of these adipokines by adipocytes. Leptin gene expression and secretion by cultured human primary adipocytes and Simpson-Golabi-Behmel Syndrome adipocytes increased upon coculture with human enterocytic Caco-2 cells or incubation in conditioned medium of Caco-2 cells. Although adiponectin secretion increased, its mRNA levels decreased. Tissue homogenate of the ileum (but not the jejunum, colon, or liver) of nonobese C57BL/6J mice also stimulated leptin and adiponectin secretion by cultured murine 3T3-L1 adipocytes. However, ileal homogenate of obese KK-Ay mice had no effect on leptin and adiponectin secretion. We propose that as yet unidentified humoral factors released from intestinal epithelial cells are involved in regulating circulating leptin and adiponectin levels. Decreased production of such factors may contribute to hyperphagia in KK-Ay mice. (C) 2015 Elsevier Inc. All rights reserved.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 園山 慶

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