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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes
| Title: | Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes |
| Authors: | Ishihara, Rino Browse this author | | Mizuno, Yuki Browse this author | | Miwa, Akiho Browse this author | | Hamada, Akihiro Browse this author | | Tsuruta, Takeshi Browse this author | | Wabitsch, Martin Browse this author | | Sonoyama, Kei Browse this author →KAKEN DB |
| Keywords: | Leptin | | Adiponectin | | Adipocyte | | Intestine |
| Issue Date: | 7-Mar-2015 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and biophysical research communications |
| Volume: | 458 |
| Issue: | 2 |
| Start Page: | 362 |
| End Page: | 368 |
| Publisher DOI: | 10.1016/j.bbrc.2015.01.118 |
| PMID: | 25656573 |
| Abstract: | Although leptin and adiponectin are the predominant adipokines, how their circulating levels are regulated is incompletely understood. The present study tested whether intestinal epithelial cells influence the expression and secretion of these adipokines by adipocytes. Leptin gene expression and secretion by cultured human primary adipocytes and Simpson-Golabi-Behmel Syndrome adipocytes increased upon coculture with human enterocytic Caco-2 cells or incubation in conditioned medium of Caco-2 cells. Although adiponectin secretion increased, its mRNA levels decreased. Tissue homogenate of the ileum (but not the jejunum, colon, or liver) of nonobese C57BL/6J mice also stimulated leptin and adiponectin secretion by cultured murine 3T3-L1 adipocytes. However, ileal homogenate of obese KK-Ay mice had no effect on leptin and adiponectin secretion. We propose that as yet unidentified humoral factors released from intestinal epithelial cells are involved in regulating circulating leptin and adiponectin levels. Decreased production of such factors may contribute to hyperphagia in KK-Ay mice. (C) 2015 Elsevier Inc. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/60792 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 園山 慶
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